Course detail

Special Toxicology

FCH-MCO_STXAcad. year: 2018/2019

History, the field of toxicology, definition of dose-response relationship, toxicity, interactions of substances at different levels. Toxicological characteristics of elements, inorganic and organic compounds, organometallic compounds, alkaloids, biologically active substances, natural toxins of fungi, algae, plants and animals. Radiotoxicology and warfare agents.

Learning outcomes of the course unit

Students will gain new knowledge, understanding and knowledge in the following areas

1st Students will be capable of application concepts in the field of special toxicology and other chemical and toxicological fields.
2nd Students will gain knowledge of mechanisms of toxic effects on organisms, students will know the different types of toxic effects, students will understand the impact factors (external and internal) on the toxicity of substances.
3rd Students gain knowledge of toxicity of elements and their compounds, selected organic compounds, organometallic compounds, alkaloids, biologically active substances, toxins of fungi, algae, plants, animals.
4th Students gain knowledge of radiotoxicology, warfare agents.

Prerequisites

Knowledge of general toxicology, inorganic, organic chemistry, environmental chemistry, biochemistry.

Co-requisites

Not applicable.

Recommended optional programme components

Not applicable.

Recommended or required reading

Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995; (CS)
Ecobichon, J.D., The Basis of Toxicity Testing, CRC Press, Boca Raton 1997. (CS)
Hodgson, E., Levi P. E., A Textbook of Modern Toxicology, Elsevier Sci. Publ., New York, Amsterdam, London, 1987 (CS)
Doležalová: Elearningové studijní opory,https://www.vutbr.cz/elearning/course/view.php?id=122024 (CS)
Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)
Marhold, J., Přehled průmyslové toxikologie, Anorganické látky.Organické látky, Avicenum, Praha 1980,1986 (CS)
Ernest Hodgson , A Textbook of Modern Toxicology, 2011, Willey (CS)
Lindsay Murray, Frank Daly, Mike Cadogan , Toxicology Handbook, 2011, Elsevier (CS)
http://toxnet.nlm.nih.gov/ (CS)
Casarett and Doull's Toxicology - The Basic Science of Poisons, http:https://accesspharmacy.mhmedical.com/book.aspx?bookID=958#53483719 (CS)
Doležalová: Studijní opory.https://www.vutbr.cz/elearning/course (CS)
Stephen M. Roberts, Robert C. James, Phillip L. Williams, Principles of toxicology : environmental and industrial applications, John Wiley and Sons, Inc., 2015 (CS)

Planned learning activities and teaching methods

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Assesment methods and criteria linked to learning outcomes

Test in the form of written test along with the oral exam in the range of lectures and recommended literature.

Language of instruction

Czech

Work placements

Not applicable.

Course curriculum

1. History, definition of special toxicology, terminology, principles.
2. Overview of toxic effects of toxic compounds, characteristics, examples of toxic compounds and toxins.
3. Toxicological characteristics of elements, inorganic, organic compounds and organometallic compounds.
4. Toxicological characteristics of selected organic groups and compounds.
5. Toxicological characteristics of fungi, cyanobacteria, algae toxins.
6. Toxicological characteristics of plant toxins Toxicologically important plant species (alkaloids, biologically active substances)
7. Toxicological characteristics of animal toxins, toxicologically significant animal species.
8th Radiotoxicology Toxicology and chemical warfare agents.

Aims

The aim is to provide and clarify the toxic effects of substances and mechanisms of toxic effects on organisms, toxic effects of elements and their compounds, selected organic compounds, alkaloids, biologically active substances, toxins of fungi, algae, plants, animals, radiotoxicology, warfare agents.

Specification of controlled education, way of implementation and compensation for absences

Attendance at lectures is recommended, but not controlled. An integral part of teaching and combined form of teaching is a e-learning tutorial course, divided into blocks, within which are available to students learning support including electronic textbooks, presentations, lectures, and other complementary materials.For students in combined form of study are organized consultations on the topics for full-time students.Consultations are also provided to full-time students on request.

Classification of course in study plans

  • Programme NKCP_CHTOZP Master's

    branch NKCO_CHTOZP , 1. year of study, winter semester, 3 credits, compulsory

  • Programme NPCP_CHTOZP Master's

    branch NPCO_CHTOZP , 1. year of study, winter semester, 3 credits, compulsory

  • Programme CKCP_CZV lifelong learning

    branch CKCO_CZV , 1. year of study, winter semester, 3 credits, compulsory

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer