Course detail

Molecular Genetics I

FCH-BCO_MOG1Acad. year: 2018/2019

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms.

Learning outcomes of the course unit

The basic knowledge of molecular biology, using methods of molecular biology and gene engineering in the research area, in industry, agriculture and medicine.

Prerequisites

The structure and basic functions of living systems, their reproduction, cell chemistry, structure and function of biomacromolecules.

Co-requisites

Not applicable.

Recommended optional programme components

Not applicable.

Recommended or required reading

Rosypal S. a kol.: Úvod do molekulární biologie. S. Rosypal, Brno 2006. (CS)
Watson, J.D. et al.: Recombinant DNA, W.H.Freeman, New York 1992. (CS)
Griffith, A.J.E.: An introduction to genetic analysis. W. H. Freeman and Comp., New York 2004. (CS)
Sundstad P., Simmons M.J. Genetika. Český překlad, Masarykova univerzita, Brno 2009 (CS)

Planned learning activities and teaching methods

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Assesment methods and criteria linked to learning outcomes

Oral exam

Language of instruction

Czech

Work placements

Not applicable.

Course curriculum

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms. Gene therapy. Genetic diseases and their diagnostics. Molecular genetics of plants and their use in agriculture.

Aims

This lecture is conceived as an introduction into molecular biology and genetics and gives the explanation of processes on molecular level in relation to the basic functions of living systems. The second part of the lecture is focused on basic methods of molecular genetics and their applications in gene engineering which is a main tool of modern biotechnologies.

Specification of controlled education, way of implementation and compensation for absences

Lectures are optional, no control tests during the semester

Classification of course in study plans

  • Programme BPCP_CHCHT Bachelor's

    branch BPCO_CHMN , 3. year of study, winter semester, 4 credits, compulsory-optional

  • Programme BKCP_CHTP Bachelor's

    branch BKCO_BT , 3. year of study, winter semester, 4 credits, compulsory

  • Programme BPCP_CHTP Bachelor's

    branch BPCO_BT , 3. year of study, winter semester, 4 credits, compulsory

  • Programme BKCP_CHTP Bachelor's

    branch BKCO_PCH , 3. year of study, winter semester, 4 credits, compulsory-optional

  • Programme BPCP_CHTP Bachelor's

    branch BPCO_CHP , 3. year of study, winter semester, 4 credits, compulsory-optional

  • Programme IT-MGR-2 Master's

    branch MBI , 1. year of study, winter semester, 3 credits, compulsory

  • Programme CKCP_CZV lifelong learning

    branch CKCO_CZV , 1. year of study, winter semester, 4 credits, compulsory-optional

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer