prof. Ing. Ivo Provazník, Ph.D.

Department of Biomedical Engineering (UBMI)

Students will be able to:
- mathematically describe the main components of gene expression
- mathematically describe the main components of signal transduction pathways
- mathematically describe the main components of neuronal pathways
- analyze network graphs using network motifs
- name the main network motifs of transcription, signal-transduction and neuronal-system networks
- explain principles of the main network motifs of transcription, signal-transduction and neuronal-system networks
- describe experimental mathods in systems biology

Students enrolled in this subject should be able to describe cellular systems, its main components regarding structure and function; analyze systems of ordinary differential equations and apply basic knowledge of probability distribution and combinatorics. In general, knowledge on the Bachelor's degree level is requested.

Not applicable.

Not applicable.

Konopka, A.K. Systems Biology: Principles, Methods, and Concepts. CRC, 2006, ISBN: 978-0824725204 (EN)
Klipp, E., Liebermeister, W., Wierling, C., Kowald, A., Lehrach, H., Herwig, R. Systems Biology: A Textbook. Wiley, 2009. ISBN: 978-3-527-31874-2 (EN)
Alon, U: An Introduction to Systems Biology, Design Principles of Biological Circuits. CRC, 2007, ISBN: 1-58488-642-0 (EN)
Maly, Ivan V. Systems biology. Humana Press, New York 2009. ISBN 978-1-934115-64-0. (CS)
Rosypal, S. Nový přehled biologie. Scientia, Praha 2003. ISBN 80-7183-268-5 (CS)
Dubitzky, W., Wolkenhauer, O., Cho, K.-H., Yokota, H., Encyclopedia of systems biology. Springer, New York 2013. ISBN 978-144-1998-644. (CS)

Techning methods include lectures and computer laboratories. Course is taking advantage of e-learning (Moodle) system.

upto 30 points from laboratories
upto 70 points from examination.
Examination has an on-line form.

Czech

Not applicable.

The aim of the subject is to provide students with basic knowledge of computational models in cellular biology and way of their use, knowledge of analysis methods applied to models in systems biology.

Laboratory tutorials are compulsory, properly justified absence can be compensated based on agreement of the tutor (usually in the last semester week).

• Programme IT-MGR-2 Master's

  branch MBI , any year of study, summer semester, 5 credits, optional
  

• Programme MPC-BTB Master's, 1. year of study, summer semester, 5 credits, compulsory
  

• Programme EEKR-CZV lifelong learning

  branch ET-CZV , 1. year of study, summer semester, 5 credits, compulsory
  

26 hours, compulsory

Ing. Kateřina Jurečková
Ing. Jana Musilová

eLearning: currently opened course