Publication detail

Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates

MOTOLA, M. ČAPEK, J. ZAZPE MENDIOROZ, R. BAČOVÁ, J. HROMÁDKO, L. BRŮČKOVÁ, L. NG, S. HANDL, J. SPOTZ, Z. KNOTEK, P. BAISHYA, K. MAJTNEROVÁ, P. PŘIKRYL, J. SOPHA, H. ROUŠAR, T. MACÁK, J.

Original Title

Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates

Type

journal article in Web of Science

Language

English

Original Abstract

The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials’ biocompatibility and is promising toward application in implant materials.

Keywords

TiO2 nanotube layers, Ti sheets, atomic layer deposition, coatings, cell growth

Authors

MOTOLA, M.; ČAPEK, J.; ZAZPE MENDIOROZ, R.; BAČOVÁ, J.; HROMÁDKO, L.; BRŮČKOVÁ, L.; NG, S.; HANDL, J.; SPOTZ, Z.; KNOTEK, P.; BAISHYA, K.; MAJTNEROVÁ, P.; PŘIKRYL, J.; SOPHA, H.; ROUŠAR, T.; MACÁK, J.

Released

21. 9. 2020

Publisher

American Chemical Society

ISBN

2576-6422

Periodical

ACS Applied Bio Materials

Year of study

3

Number

9

State

United States of America

Pages from

6447

Pages to

6456

Pages count

10

URL

https://pubs.acs.org/doi/10.1021/acsabm.0c00871

Full text in the Digital Library

http://hdl.handle.net/11012/196522

BibTex

@article{BUT167263,
  author="Martin {Motola} and Jan {Čapek} and Raúl {Zazpe Mendioroz} and Jana {Bačová} and Luděk {Hromádko} and Lenka {Brůčková} and Siow Woon {Ng} and Jiří {Handl} and Zdeněk {Spotz} and Petr {Knotek} and Kaushik {Baishya} and Pavlína {Majtnerová} and Jan {Přikryl} and Hanna Ingrid {Sopha} and Tomáš {Roušar} and Jan {Macák}",
  title="Thin TiO2Coatings by ALD Enhance the Cell Growth on TiO2Nanotubular and Flat Substrates",
  journal="ACS Applied Bio Materials",
  year="2020",
  volume="3",
  number="9",
  pages="6447--6456",
  doi="10.1021/acsabm.0c00871",
  issn="2576-6422",
  url="https://pubs.acs.org/doi/10.1021/acsabm.0c00871"
}