Publication detail

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

PEKAŘÍK, V. PEŠKOVÁ, M. DUBEN, J. REMEŠ, M. HEGER, Z.

Original Title

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

Type

journal article in Web of Science

Language

English

Original Abstract

Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.

Keywords

fluorogenic detection; palladium; platinum; organometallic compounds; polyacrylamide gels

Authors

PEKAŘÍK, V.; PEŠKOVÁ, M.; DUBEN, J.; REMEŠ, M.; HEGER, Z.

Released

23. 7. 2020

Publisher

Springer Nature

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

10

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

10

Pages count

10

URL

https://www.nature.com/articles/s41598-020-69336-w

Full text in the Digital Library

http://hdl.handle.net/11012/194807

BibTex

@article{BUT164788,
  author="Vladimír {Pekařík} and Marie {Pešková} and Jakub {Duben} and Marek {Remeš} and Zbyněk {Heger}",
  title="Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels",
  journal="Scientific Reports",
  year="2020",
  volume="10",
  number="1",
  pages="1--10",
  doi="10.1038/s41598-020-69336-w",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-020-69336-w"
}