Detail publikace

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

PEKAŘÍK, V. PEŠKOVÁ, M. DUBEN, J. REMEŠ, M. HEGER, Z.

Originální název

Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.

Klíčová slova

fluorogenic detection; palladium; platinum; organometallic compounds; polyacrylamide gels

Autoři

PEKAŘÍK, V.; PEŠKOVÁ, M.; DUBEN, J.; REMEŠ, M.; HEGER, Z.

Vydáno

23. 7. 2020

Nakladatel

Springer Nature

ISSN

2045-2322

Periodikum

Scientific Reports

Ročník

10

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

10

Strany počet

10

URL

https://www.nature.com/articles/s41598-020-69336-w

Plný text v Digitální knihovně

http://hdl.handle.net/11012/194807

BibTex

@article{BUT164788,
  author="Vladimír {Pekařík} and Marie {Pešková} and Jakub {Duben} and Marek {Remeš} and Zbyněk {Heger}",
  title="Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels",
  journal="Scientific Reports",
  year="2020",
  volume="10",
  number="1",
  pages="1--10",
  doi="10.1038/s41598-020-69336-w",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-020-69336-w"
}