Publication detail

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

DUROVIC, A. STOJANOVIC, Z. KRAVIC, S. KOS, J. RICHTERA, L.

Original Title

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

Type

journal article in Web of Science

Language

English

Original Abstract

A sensitive square-wave voltammetry method was developed to determine cholecalciferol (vitamin D-3) in pharmaceutical products at boron-doped diamond electrode as a working electrode. Vitamin D-3 provided a well-defined voltammetric peak at around +1.00 V (vs. Ag/AgCl, 3.5 mol dm(-3)) in 0.02 mol dm(-3) Britton-Robinson buffer pH 5.0 prepared in 50 % ethanol. The influence of various factors such as type and pH of the supporting electrolyte, scan rate and square-wave parameters were studied and optimized. Under optimum conditions, the oxidation peak current increased linearly with the concentration of vitamin D-3 over the range of 2 to 200 mu mol dm(-3). The calculated limit of detection and limit of quantitation were 0.17 mu mol dm(-3) and 0.51 mu mol dm(-3), respectively. The boron-doped diamond electrode exhibited specific recognition capability for cholecalciferol amongst possible interferences, and the determination of vitamin D-3 was possible in samples such as commercial pharmaceutical products without complicated sample pretreatments.

Keywords

Boron doped diamond electrode; Pharmaceutical samples; Sensors; Vitamin D; Voltammetry

Authors

DUROVIC, A.; STOJANOVIC, Z.; KRAVIC, S.; KOS, J.; RICHTERA, L.

Released

30. 4. 2020

ISBN

1040-0397

Periodical

ELECTROANALYSIS

Year of study

32

Number

4

State

Federal Republic of Germany

Pages from

741

Pages to

748

Pages count

8

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/elan.201900532

BibTex

@article{BUT161351,
  author="Ana {Durovic} and Zorica {Stojanovic} and Snezana {Kravic} and Jovana {Kos} and Lukáš {Richtera}",
  title="Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode",
  journal="ELECTROANALYSIS",
  year="2020",
  volume="32",
  number="4",
  pages="741--748",
  doi="10.1002/elan.201900532",
  issn="1040-0397",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/elan.201900532"
}