Detail publikace

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Originální název

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Anglický název

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Jazyk

en

Originální abstrakt

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Anglický abstrakt

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

BibTex


@article{BUT96584,
  author="Helena {Škutková} and Petr {Babula} and Marie {Stiborová} and Tomáš {Eckschlager} and Libuše {Trnková} and Ivo {Provazník} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review",
  annote="Mammalian  metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous 
functions  including toxic metal detoxification, as a metal chaperone and maintenance of metal ion 
homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals.  In this 
review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and 
their connection with cancerogenesis and cancer diagnostics are described. The interesting properties 
of MTs are closely related with structure, which can be studied by modern bioinformatics approaches 
and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.",
  chapter="96584",
  number="7",
  volume="2012",
  year="2012",
  month="december",
  pages="12415--12431",
  type="journal article in Web of Science"
}