Detail publikace

Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

SALAS-GARCÍA, I. FANJUL-VÉLEZ, F. ORTEGA-QUIJANO, N. POLIAK, J. HUDCOVÁ, L. WILFERT, O. ARCE-DIEGO, J.

Originální název

Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

Český název

Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles

Typ

článek ve sborníku

Jazyk

cs

Originální abstrakt

One of the emerging strategies to overcome the actual drawbacks in Photodynamic Therapy is its combination with nanoparticles. Specifically, the administration of gold nanoparticles to the pathological tissue causes an increase in the optical radiation absorption that could lead to induce thermal damage in the target tissue. However, photodynamic therapy is based on photochemical interactions and therefore it is necessary to study possible thermal interactions that might occur in the target tissue due to the administration of nanoparticles. In this work we present a thermal model that tries to predict the effect of gold nanoparticles in the local heating for three different types of malignant skin tumors subjected to typical power densities applied in photodynamic therapy. The results obtained show a negligible increase in the local temperature that demonstrates the absence of thermal damage under the irradiation conditions commonly applied in photodynamic therapy clinical practice.

Český abstrakt

One of the emerging strategies to overcome the actual drawbacks in Photodynamic Therapy is its combination with nanoparticles. Specifically, the administration of gold nanoparticles to the pathological tissue causes an increase in the optical radiation absorption that could lead to induce thermal damage in the target tissue. However, photodynamic therapy is based on photochemical interactions and therefore it is necessary to study possible thermal interactions that might occur in the target tissue due to the administration of nanoparticles. In this work we present a thermal model that tries to predict the effect of gold nanoparticles in the local heating for three different types of malignant skin tumors subjected to typical power densities applied in photodynamic therapy. The results obtained show a negligible increase in the local temperature that demonstrates the absence of thermal damage under the irradiation conditions commonly applied in photodynamic therapy clinical practice.

Klíčová slova

Nanoparticles; light propagation; thermal effects

Rok RIV

2012

Vydáno

17.04.2012

ISBN

978-80-214-4468-3

Kniha

Proceedings of 22nd International Conference Radioelektronika 2012

Strany od

183

Strany do

186

Strany počet

4

BibTex


@inproceedings{BUT91424,
  author="Irene {Salas-García} and Félix {Fanjul-Vélez} and Noé {Ortega-Quijano} and Juraj {Poliak} and Lucie {Hudcová} and Otakar {Wilfert} and José Luis {Arce-Diego}",
  title="Heat Generation in Biological Tissues during Photodynamic Therapy combined with Gold Nanoparticles",
  annote="One of the emerging strategies to overcome the actual drawbacks in Photodynamic Therapy is its combination with nanoparticles. Specifically, the administration of gold nanoparticles to the pathological tissue causes an increase in the optical radiation absorption that could lead to induce thermal damage in the target tissue. However, photodynamic therapy is based on photochemical interactions and therefore it is necessary to study possible thermal interactions that might occur in the target tissue due to the administration of nanoparticles. In this work we present a thermal model that tries to predict the effect of gold nanoparticles in the local heating for three different types of malignant skin tumors subjected to typical power densities applied in photodynamic therapy. The results obtained show a negligible increase in the local temperature that demonstrates the absence of thermal damage under the irradiation conditions commonly applied in photodynamic therapy clinical practice.",
  booktitle="Proceedings of 22nd International Conference Radioelektronika 2012",
  chapter="91424",
  howpublished="print",
  year="2012",
  month="april",
  pages="183--186",
  type="conference paper"
}