Detail publikace

Vývoj realistického modelu lidských dýchacích cest

LÍZAL, F. ELCNER, J. HOPKE, P. JEDELSKÝ, J. JÍCHA, M.

Originální název

Development of a realistic human airway model

Český název

Vývoj realistického modelu lidských dýchacích cest

Anglický název

Development of a realistic human airway model

Typ

článek v časopise

Jazyk

en

Originální abstrakt

Numerous models of human lungs with various levels of idealization have been reported in the literature; consequently, results acquired using these models are difficult to compare to in vivo measurements. We have developed a set of model components based on realistic geometries, which permits the analysis of the effects of subsequent model simplification. A realistic digital upper airway geometry except for the lack of an oral cavity has been created which proved suitable both for computational fluid dynamics (CFD) simulations and for the fabrication of physical models. Subsequently, an oral cavity was added to the tracheobronchial geometry. The airway geometry including the oral cavity was adjusted to enable fabrication of a semi-realistic model. Five physical models were created based on these three digital geometries. Two optically transparent models, one with and one without the oral cavity, were constructed for flow velocity measurements, two realistic segmented models, one with and one without the oral cavity, were constructed for particle deposition measurements, and a semi-realistic model with glass cylindrical airways was developed for optical measurements of flow velocity and in situ particle size measurements. One-dimensional phase doppler anemometry measurements were made and compared to the CFD calculations for this model and good agreement was obtained.

Český abstrakt

V předchozích letech bylo vyvinuto mnoho idealizovaných modelů dýchacích cest, avšak výsledky získané jejich použitím je obtížné porovnat s výsledky získanými in vivo měřením kvůli různému stupni idealizace tvaru dýchacích cest. Z toho důvodu jsme vyvinuli nový realistický model na základě skutečné geometrie plic. Geometrie tohoto modelu je vhodná jak pro použití pro numerické simulace, tak i pro výrobu fyzických modelů pro in vitro měření. Článek se zabývá procesem vytváření digitalní geometrie modelu a postupy fyzické výroby realistického modelu opticky transparentního, dále modelu segmentového pro měření depozice aerosolu a výrobou semirealistického modelu pro optická i depoziční měření.

Anglický abstrakt

Numerous models of human lungs with various levels of idealization have been reported in the literature; consequently, results acquired using these models are difficult to compare to in vivo measurements. We have developed a set of model components based on realistic geometries, which permits the analysis of the effects of subsequent model simplification. A realistic digital upper airway geometry except for the lack of an oral cavity has been created which proved suitable both for computational fluid dynamics (CFD) simulations and for the fabrication of physical models. Subsequently, an oral cavity was added to the tracheobronchial geometry. The airway geometry including the oral cavity was adjusted to enable fabrication of a semi-realistic model. Five physical models were created based on these three digital geometries. Two optically transparent models, one with and one without the oral cavity, were constructed for flow velocity measurements, two realistic segmented models, one with and one without the oral cavity, were constructed for particle deposition measurements, and a semi-realistic model with glass cylindrical airways was developed for optical measurements of flow velocity and in situ particle size measurements. One-dimensional phase doppler anemometry measurements were made and compared to the CFD calculations for this model and good agreement was obtained.

Klíčová slova

model lidských dýchacích cest, tracheobronchiální strom, transport aerosolu, depozice částic, ústní dutina

Rok RIV

2012

Vydáno

17.02.2012

Nakladatel

SAGE PUBLICATIONS LTD

Místo

London

Strany od

197

Strany do

207

Strany počet

11

URL

BibTex


@article{BUT76135,
  author="František {Lízal} and Jakub {Elcner} and Philip K. {Hopke} and Jan {Jedelský} and Miroslav {Jícha}",
  title="Development of a realistic human airway model",
  annote="Numerous models of human lungs with various levels of idealization have been reported in the literature; consequently, results acquired using these models are difficult to compare to in vivo measurements. We have developed a set of model components based on realistic geometries, which permits the analysis of the effects of subsequent model simplification. A realistic digital upper airway geometry except for the lack of an oral cavity has been created which proved suitable both for computational fluid dynamics (CFD) simulations and for the fabrication of physical models. Subsequently, an oral cavity was added to the tracheobronchial geometry. The airway geometry including the oral cavity was adjusted to enable fabrication of a semi-realistic model. Five physical models were created based on these three digital geometries. Two optically transparent models, one with and one without the oral cavity, were constructed for flow velocity measurements, two realistic segmented models, one with and one without the oral cavity, were constructed for particle deposition measurements, and a semi-realistic model with glass cylindrical airways was developed for optical measurements of flow velocity and in situ particle size measurements. One-dimensional phase doppler anemometry measurements were made and compared to the CFD calculations for this model and good agreement was obtained.",
  address="SAGE PUBLICATIONS LTD",
  chapter="76135",
  institution="SAGE PUBLICATIONS LTD",
  number="H3",
  volume="226",
  year="2012",
  month="february",
  pages="197--207",
  publisher="SAGE PUBLICATIONS LTD",
  type="journal article"
}