Detail publikace

Time- And Time-Frequency Analysis Of Contractility And Desensitization In Multicellular Heart Preparations

Originální název

Time- And Time-Frequency Analysis Of Contractility And Desensitization In Multicellular Heart Preparations

Anglický název

Time- And Time-Frequency Analysis Of Contractility And Desensitization In Multicellular Heart Preparations

Jazyk

en

Originální abstrakt

The aim of this study was to examine the effect of sigma receptor ligand haloperidol in guinea pig atrial preparations. Stimulated contractions were recorded and analysed by time- and time-frequency methods. The analysis revealed that the compound exerts marked positive inotropic effect. This was significantly less pronounced in case of repeated drug administration. We conclude that sigma recep-tors in guinea pig atria undergo a desensitization process.

Anglický abstrakt

The aim of this study was to examine the effect of sigma receptor ligand haloperidol in guinea pig atrial preparations. Stimulated contractions were recorded and analysed by time- and time-frequency methods. The analysis revealed that the compound exerts marked positive inotropic effect. This was significantly less pronounced in case of repeated drug administration. We conclude that sigma recep-tors in guinea pig atria undergo a desensitization process.

BibTex


@inproceedings{BUT4660,
  author="Marie {Nováková} and Ivo {Provazník}",
  title="Time- And Time-Frequency Analysis Of Contractility And Desensitization In Multicellular Heart Preparations",
  annote="The aim of this study was to examine the effect of sigma receptor ligand haloperidol in guinea pig atrial preparations. Stimulated contractions were recorded and analysed by time- and time-frequency methods. The analysis revealed that the compound exerts marked positive inotropic effect. This was significantly less pronounced in case of repeated drug administration. We conclude that sigma recep-tors in guinea pig atria undergo a desensitization process.",
  address="Verlag der Technischen Universitat Graz",
  booktitle="IFMBE Proceedings of EMBEC'02",
  chapter="4660",
  institution="Verlag der Technischen Universitat Graz",
  year="2002",
  month="december",
  pages="554",
  publisher="Verlag der Technischen Universitat Graz",
  type="conference paper"
}