Detail publikace

Preparation and characterisation of functionalized wound dressings

DZURICKÁ, L. BENDOVÁ, A. HOOVÁ, J. MATOUŠKOVÁ, P. MÁROVÁ, I.

Originální název

Preparation and characterisation of functionalized wound dressings

Anglický název

Preparation and characterisation of functionalized wound dressings

Jazyk

en

Originální abstrakt

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Anglický abstrakt

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Dokumenty

BibTex 


@misc{BUT166180,
  author="Lucia {Dzurická} and Agáta {Bendová} and Julie {Hoová} and Petra {Matoušková} and Ivana {Márová}",
  title="Preparation and characterisation of functionalized wound dressings",
  annote="This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber  dressings  were  constituted  from  poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers  were  assembled  by  electrospinning  and  force  spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also  evaluated.  the  results  showed  good  antimicrobial  efficacy of functionalized materials.",
  address="Vysoké učení technické v Brně, Fakulta chemická",
  booktitle="Studentská odborná konference CHEMIE JE ŽIVOT 2020 Sborník abstraktů",
  chapter="166180",
  howpublished="online",
  institution="Vysoké učení technické v Brně, Fakulta chemická",
  year="2020",
  month="november",
  pages="59--60",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  type="abstract"
}