Detail publikace

Experimental and computational modelling of flow of fibres in human airways

Originální název

Experimental and computational modelling of flow of fibres in human airways

Anglický název

Experimental and computational modelling of flow of fibres in human airways

Jazyk

en

Originální abstrakt

The ability of fibres to align with the flow has been identified as a reason for higher penetration of fibres into the lungs compared to spherical particles by many studies. However, prediction of the fate of inhaled fibres by computational methods is complicated due to the necessary mathematical apparatus and the lack of experimental data for validation. It is common to apply coefficients accounting for the preferential orientation of the fibre flowing through the airways. A new experimental rig has been built to visualize the flow of micron-sized fibres and record the angles of their rotation upstream and downstream of a single bifurcation. The recorded angles are statistically analysed and improved coefficients of fibre orientation will be calculated. The experimental rig consists of a dielectrophoretic classifier of fibres, the model of human trachea and first bronchi, a breathing simulator and a high-speed camera with appropriate illumination. These experiments are supplemented with computational simulations and experimental measurement of deposition of fibres in a replica of human lungs comprising of the upper airways and first seven generations of tracheobronchial tree branching

Anglický abstrakt

The ability of fibres to align with the flow has been identified as a reason for higher penetration of fibres into the lungs compared to spherical particles by many studies. However, prediction of the fate of inhaled fibres by computational methods is complicated due to the necessary mathematical apparatus and the lack of experimental data for validation. It is common to apply coefficients accounting for the preferential orientation of the fibre flowing through the airways. A new experimental rig has been built to visualize the flow of micron-sized fibres and record the angles of their rotation upstream and downstream of a single bifurcation. The recorded angles are statistically analysed and improved coefficients of fibre orientation will be calculated. The experimental rig consists of a dielectrophoretic classifier of fibres, the model of human trachea and first bronchi, a breathing simulator and a high-speed camera with appropriate illumination. These experiments are supplemented with computational simulations and experimental measurement of deposition of fibres in a replica of human lungs comprising of the upper airways and first seven generations of tracheobronchial tree branching

BibTex


@misc{BUT157516,
  author="František {Lízal} and Jakub {Elcner} and Jan {Jedelský} and Árpád {Farkas} and Milan {Malý} and Ondřej {Pech} and Ondrej {Mišík} and Miroslav {Jícha}",
  title="Experimental and computational modelling of flow of fibres in human airways",
  annote="The ability of fibres to align with the flow has been identified as a reason for higher penetration of fibres into the lungs compared to spherical particles by many studies. However, prediction of the fate of inhaled fibres by computational methods is complicated due to the necessary mathematical apparatus and the lack of experimental data for validation. It is common to apply coefficients accounting for the preferential orientation of the fibre flowing through the airways. A new experimental rig has been built to visualize the flow of micron-sized fibres and record the angles of their rotation upstream and downstream of a single bifurcation. The recorded angles are statistically analysed and improved coefficients of fibre orientation will be calculated. The experimental rig consists of a dielectrophoretic classifier of fibres, the model of human trachea and first bronchi, a breathing simulator and a high-speed camera with appropriate illumination. These experiments are supplemented with computational simulations and experimental measurement of deposition of fibres in a replica of human lungs comprising of the upper airways and first seven generations of tracheobronchial tree branching",
  address="MARY ANN LIEBERT, INC",
  chapter="157516",
  howpublished="print",
  institution="MARY ANN LIEBERT, INC",
  number="3",
  year="2019",
  month="june",
  pages="1--1",
  publisher="MARY ANN LIEBERT, INC",
  type="abstract"
}