Detail publikace

Effects of non-invasive brain stimulation of the superior temporal gyrus on motor speech disorder in Parkinson's disease

Originální název

Effects of non-invasive brain stimulation of the superior temporal gyrus on motor speech disorder in Parkinson's disease

Anglický název

Effects of non-invasive brain stimulation of the superior temporal gyrus on motor speech disorder in Parkinson's disease

Jazyk

en

Originální abstrakt

Background and aims: Hypokinetic dysarthria (HD) is a common symptom of Parkinson’s disease (PD) which does not respond well to PD treatments. We investigated short-term effects of repetitive transcranial magnetic stimulation (rTMS) on HD in PD using acoustic analysis of speech. The main objective was to identify an optimal rTMS protocol and stimulation site to improve specific symptoms of HD in PD.Methods: We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the right posterior superior temporal gyrus (STG), the left orofacial primary motor area (OFM1), and over the vertex (V, a control stimulation site) in 10 PD patients with mild to moderate HD and 4 age-matched healthy controls. Stimulation sites and protocols were randomised across subjects and sessions. A cross-over design was used. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. The study is ongoing and neural (fMRI) correlates of stimulation-induced changes will also be assessed.Results: The preliminary results show particularly effects (p<0.05 in Wilcoxon test) of 1 Hz rTMS of the STG on total pause time, std of the 2nd formant, std of the fundamental voice frequency, and speech index of rhythmicity in PD, while some effects of 10 Hz rTMS of the OFM1 were also observed. Conclusion: Preliminary results demonstrate for the first time that low-frequency stimulation of the right STG may improve articulation, rhythmicity, intonation and pausing of speech in PD with HD. The study is ongoing.

Anglický abstrakt

Background and aims: Hypokinetic dysarthria (HD) is a common symptom of Parkinson’s disease (PD) which does not respond well to PD treatments. We investigated short-term effects of repetitive transcranial magnetic stimulation (rTMS) on HD in PD using acoustic analysis of speech. The main objective was to identify an optimal rTMS protocol and stimulation site to improve specific symptoms of HD in PD.Methods: We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the right posterior superior temporal gyrus (STG), the left orofacial primary motor area (OFM1), and over the vertex (V, a control stimulation site) in 10 PD patients with mild to moderate HD and 4 age-matched healthy controls. Stimulation sites and protocols were randomised across subjects and sessions. A cross-over design was used. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. The study is ongoing and neural (fMRI) correlates of stimulation-induced changes will also be assessed.Results: The preliminary results show particularly effects (p<0.05 in Wilcoxon test) of 1 Hz rTMS of the STG on total pause time, std of the 2nd formant, std of the fundamental voice frequency, and speech index of rhythmicity in PD, while some effects of 10 Hz rTMS of the OFM1 were also observed. Conclusion: Preliminary results demonstrate for the first time that low-frequency stimulation of the right STG may improve articulation, rhythmicity, intonation and pausing of speech in PD with HD. The study is ongoing.

BibTex


@misc{BUT145760,
  author="Luboš {Brabenec} and Jiří {Mekyska} and Zoltán {Galáž} and Vojtěch {Zvončák} and Tomáš {Kiska} and Ján {Mucha} and Zdeněk {Smékal} and Milena {Košťálová} and Irena {Rektorová}",
  title="Effects of non-invasive brain stimulation of the superior temporal gyrus on motor speech disorder in Parkinson's disease",
  annote="Background and aims: Hypokinetic dysarthria (HD) is a common symptom of Parkinson’s disease (PD) which does not respond well to PD treatments. We investigated short-term effects of repetitive transcranial magnetic stimulation (rTMS) on HD in PD using acoustic analysis of speech. The main objective was to identify an optimal rTMS protocol and stimulation site to improve specific symptoms of HD in PD.Methods: We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the right posterior superior temporal gyrus (STG), the left orofacial primary motor area (OFM1), and over the vertex (V, a control stimulation site) in 10 PD patients with mild to moderate HD and 4 age-matched healthy controls. Stimulation sites and protocols were randomised across subjects and sessions. A cross-over design was used. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. The study is ongoing and neural (fMRI) correlates of stimulation-induced changes will also be assessed.Results: The preliminary results show particularly effects (p<0.05 in Wilcoxon test) of 1 Hz rTMS of the STG on total pause time, std of the 2nd formant, std of the fundamental voice frequency, and speech index of rhythmicity in PD, while some effects of 10 Hz rTMS of the OFM1 were also observed.  Conclusion: Preliminary results demonstrate for the first time that low-frequency stimulation of the right STG may improve articulation, rhythmicity, intonation and pausing of speech in PD with HD. The study is ongoing.",
  address="European Journal of Neurology",
  chapter="145760",
  doi="10.1111/ene.13368",
  howpublished="online",
  institution="European Journal of Neurology",
  number="S1",
  year="2017",
  month="july",
  pages="478--478",
  publisher="European Journal of Neurology",
  type="abstract"
}