Detail publikace

Experimental methods for flow and aerosol measurements in human airways and their replicas

Originální název

Experimental methods for flow and aerosol measurements in human airways and their replicas

Anglický název

Experimental methods for flow and aerosol measurements in human airways and their replicas

Jazyk

en

Originální abstrakt

Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.

Anglický abstrakt

Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given.

BibTex


@article{BUT143632,
  author="František {Lízal} and Jan {Jedelský}",
  title="Experimental methods for flow and aerosol measurements in human airways and their replicas",
  annote="Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development
of computational simulations. Although such simulations provide results in unbeatable resolution,
significant differences among distinct methods of calculation emphasize the need for highly precise experimental
data in order to specify boundary conditions and for validation purposes. This paper reviews and critically
evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory
airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways.
Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational
calculations that can be validated are indicated. The review classifies the methods into following
categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement
of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the
measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods
are described, applications in human airways studies are illustrated, and recommendations for the most useful
applications of each method are given.",
  address="Elsevier B.V.",
  chapter="143632",
  doi="10.1016/j.ejps.2017.08.021",
  howpublished="print",
  institution="Elsevier B.V.",
  number="SI",
  volume="113",
  year="2018",
  month="february",
  pages="95--131",
  publisher="Elsevier B.V.",
  type="journal article"
}