Detail publikace

The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond

Zhu, HL. Zhang, HQ. Ni, S. Korabecna, M. Yobas, L. Neuzil, P.

Originální název

The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Infectious diseases, such as the most recent case of coronavirus disease 2019, have brought the prospect of point-of-care (POC) diagnostic tests into the spotlight. A rapid, accurate, low-cost, and easy-to-use test in the field could stop epidemics before they develop into full-blown pandemics. Unfortunately, despite all the advances, it still does not exist. Here, we critically review the limited number of prototypes demonstrated to date that is based on a polymerase chain reaction (PCR) and has come close to fulfill this vision. We summarize the requirements for the POC PCR tests and then go on to discuss the PCR product-detection methods, the integration of their functional components, the potential applications, and other practical issues related to the implementation of lab-on-a-chip technologies. We conclude our review with a discussion of the latest findings on nucleic acid-based diagnosis. (C) 2020 Elsevier B.V. All rights reserved.

Klíčová slova

COVID-19 diagnoses; Polymerase chain reaction; Microfluidics; Miniaturization; Point of care; Future of PCR

Autoři

Zhu, HL.; Zhang, HQ.; Ni, S.; Korabecna, M.; Yobas, L.; Neuzil, P.

Vydáno

1. 9. 2020

Nakladatel

ELSEVIER SCI LTD

Místo

OXFORD

ISSN

0165-9936

Periodikum

TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Ročník

130

Číslo

115984

Stát

Spojené království Velké Británie a Severního Irska

Strany od

115984

Strany do

115984

Strany počet

13

URL

https://www.sciencedirect.com/science/article/pii/S0165993620302132?casa_token=Z2ZbtTb1LWcAAAAA:u6pRqpDLw8a4YLRIgJDrxE5ECMwLBKGAYLVU_7xizQgoBIyT8yQWdit6se91jm0vDmQz9Cz97A

BibTex

@article{BUT165708,
  author="Zhu, HL. and Zhang, HQ. and Ni, S. and Korabecna, M. and Yobas, L. and Neuzil, P.",
  title="The vision of point-of-care PCR tests for the COVID-19 pandemic and beyond",
  journal="TRAC-TRENDS IN ANALYTICAL CHEMISTRY",
  year="2020",
  volume="130",
  number="115984",
  pages="115984--115984",
  doi="10.1016/j.trac.2020.115984",
  issn="0165-9936",
  url="https://www.sciencedirect.com/science/article/pii/S0165993620302132?casa_token=Z2ZbtTb1LWcAAAAA:u6pRqpDLw8a4YLRIgJDrxE5ECMwLBKGAYLVU_7xizQgoBIyT8yQWdit6se91jm0vDmQz9Cz97A"
}