Detail publikace

Nanoparticle-drug conjugates treating bacterial infections

JELÍNKOVÁ, P. MAZUMDAR, A. SUR, V. KOČIOVÁ, S. DOLEŽELÍKOVÁ, K. JIMENEZ JIMENEZ, A. KOUDELKOVÁ, Z. MISHRA, P. ŠMERKOVÁ, K. HEGER, Z. VACULOVIČOVÁ, M. MOULICK, A. ADAM, V.

Originální název

Nanoparticle-drug conjugates treating bacterial infections

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The ever increasing scenario of bacterial resistance against commonly available antibiotics is becoming a global threat of major concern, which necessitates the development of new strategies to overcome this hurdle. Conjugation of nanoparticles (NPs) with antimicrobial moieties, such as antibiotics, peptides or different biomolecules, has been one of the successful techniques in targeting antibiotic resistance. This review mainly focusses on the possible nanoparticle-drug conjugates with their activity against pathogenic bacterial infections. Nanoparticles play an array of roles, e.g. as a carrier, synergistically acting agent and as theranostic agent, henceforth facilitates the efficacy of therapy. Moreover, this review elaborates the studies with reported nanoparticles-drug conjugates that include their possible synthesis methodologies and applications. In most of the cases, the nanoparticles were found to increase the permeability of bacterial cell membrane, which enables higher uptake of antibiotics inside the bacterial cells which in return showed better effects. Even the conjugates were found to efficiently kill the antibiotic-resistant strains. Since several limitations are exerted by the biological systems, there is an urge for the advancement of nanoparticle-drug conjugates for better proficiency.

Klíčová slova

Bacteria; Resistance; Antibiotics; Nanoparticle; Antimicrobial peptide; Composites

Autoři

JELÍNKOVÁ, P.; MAZUMDAR, A.; SUR, V.; KOČIOVÁ, S.; DOLEŽELÍKOVÁ, K.; JIMENEZ JIMENEZ, A.; KOUDELKOVÁ, Z.; MISHRA, P.; ŠMERKOVÁ, K.; HEGER, Z.; VACULOVIČOVÁ, M.; MOULICK, A.; ADAM, V.

Vydáno

10. 8. 2019

ISSN

0168-3659

Periodikum

JOURNAL OF CONTROLLED RELEASE

Ročník

307

Číslo

1

Stát

Nizozemsko

Strany od

166

Strany do

185

Strany počet

20

URL

https://www.sciencedirect.com/science/article/pii/S0168365919303232

BibTex

@article{BUT158952,
  author="Pavlína {Jelínková} and Aninda {Mazumdar} and Vishma Pratap {Sur} and Silvia {Kočiová} and Kristýna {Doleželíková} and Ana Maria {Jimenez Jimenez} and Zuzana {Koudelková} and Pawan Kumar {Mishra} and Kristýna {Šmerková} and Zbyněk {Heger} and Markéta {Vaculovičová} and Amitava {Moulick} and Vojtěch {Adam}",
  title="Nanoparticle-drug conjugates treating bacterial infections",
  journal="JOURNAL OF CONTROLLED RELEASE",
  year="2019",
  volume="307",
  number="1",
  pages="166--185",
  doi="10.1016/j.jconrel.2019.06.013",
  issn="0168-3659",
  url="https://www.sciencedirect.com/science/article/pii/S0168365919303232"
}