Publication detail

Nanoparticle-drug conjugates treating bacterial infections

JELÍNKOVÁ, P. MAZUMDAR, A. SUR, V. KOČIOVÁ, S. DOLEŽELÍKOVÁ, K. JIMENEZ JIMENEZ, A. KOUDELKOVÁ, Z. MISHRA, P. ŠMERKOVÁ, K. HEGER, Z. VACULOVIČOVÁ, M. MOULICK, A. ADAM, V.

Original Title

Nanoparticle-drug conjugates treating bacterial infections

Type

journal article in Web of Science

Language

English

Original Abstract

The ever increasing scenario of bacterial resistance against commonly available antibiotics is becoming a global threat of major concern, which necessitates the development of new strategies to overcome this hurdle. Conjugation of nanoparticles (NPs) with antimicrobial moieties, such as antibiotics, peptides or different biomolecules, has been one of the successful techniques in targeting antibiotic resistance. This review mainly focusses on the possible nanoparticle-drug conjugates with their activity against pathogenic bacterial infections. Nanoparticles play an array of roles, e.g. as a carrier, synergistically acting agent and as theranostic agent, henceforth facilitates the efficacy of therapy. Moreover, this review elaborates the studies with reported nanoparticles-drug conjugates that include their possible synthesis methodologies and applications. In most of the cases, the nanoparticles were found to increase the permeability of bacterial cell membrane, which enables higher uptake of antibiotics inside the bacterial cells which in return showed better effects. Even the conjugates were found to efficiently kill the antibiotic-resistant strains. Since several limitations are exerted by the biological systems, there is an urge for the advancement of nanoparticle-drug conjugates for better proficiency.

Keywords

Bacteria; Resistance; Antibiotics; Nanoparticle; Antimicrobial peptide; Composites

Authors

JELÍNKOVÁ, P.; MAZUMDAR, A.; SUR, V.; KOČIOVÁ, S.; DOLEŽELÍKOVÁ, K.; JIMENEZ JIMENEZ, A.; KOUDELKOVÁ, Z.; MISHRA, P.; ŠMERKOVÁ, K.; HEGER, Z.; VACULOVIČOVÁ, M.; MOULICK, A.; ADAM, V.

Released

10. 8. 2019

ISBN

0168-3659

Periodical

JOURNAL OF CONTROLLED RELEASE

Year of study

307

Number

1

State

Kingdom of the Netherlands

Pages from

166

Pages to

185

Pages count

20

URL

https://www.sciencedirect.com/science/article/pii/S0168365919303232

BibTex

@article{BUT158952,
  author="Pavlína {Jelínková} and Aninda {Mazumdar} and Vishma Pratap {Sur} and Silvia {Kočiová} and Kristýna {Doleželíková} and Ana Maria {Jimenez Jimenez} and Zuzana {Koudelková} and Pawan Kumar {Mishra} and Kristýna {Šmerková} and Zbyněk {Heger} and Markéta {Vaculovičová} and Amitava {Moulick} and Vojtěch {Adam}",
  title="Nanoparticle-drug conjugates treating bacterial infections",
  journal="JOURNAL OF CONTROLLED RELEASE",
  year="2019",
  volume="307",
  number="1",
  pages="166--185",
  doi="10.1016/j.jconrel.2019.06.013",
  issn="0168-3659",
  url="https://www.sciencedirect.com/science/article/pii/S0168365919303232"
}