Detail publikace

Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats

POHANKA, M. ŠTĚTINA, R. SVOBODOVÁ, H. RUTTKAY-NEDECKÝ, B. JÍLKOVÁ, M. SOCHOR, J. SOBOTKA, J. ADAM, V. KIZEK, R.

Originální název

Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Sulfur mustard (SM) is a chemical warfare agent with cytotoxic effect and a tight link to oxidative stress (OS). Depletion of antioxidants is considered as a cause of detrimental consequence and belongs to the important steps leading to cell death. The oxidative injury appearing after SM exposure is not well understood. Nevertheless, identification of the pathological processes would be a good opportunity to establish an efficient therapy. Here, we focused our effort on an estimation of reactive oxygen species homeostasis and apoptotic processes in Wistar rats exposed to 0-160 mg/kg of SM. We assayed antioxidant activity, thiobarbituric acid reactive substances, reduced glutathione/oxidized glutathione, metallothionein, glutathione reductase, glutathione peroxidase, glutathione S-transferase, caspase 3, and glucose in the livers, kidneys, and muscles of the animals. Significant OS, depletion of low-molecular-mass antioxidants, increase in caspase activity, and some other processes related to SM action were determined. Moreover, we infer a principal role of OS in the tested organs

Klíčová slova

Sulfur mustard, oxidative stress, cell death

Autoři

POHANKA, M.; ŠTĚTINA, R.; SVOBODOVÁ, H.; RUTTKAY-NEDECKÝ, B.; JÍLKOVÁ, M.; SOCHOR, J.; SOBOTKA, J.; ADAM, V.; KIZEK, R.

Rok RIV

2013

Vydáno

1. 7. 2013

ISSN

0148-0545

Periodikum

DRUG AND CHEMICAL TOXICOLOGY

Ročník

36

Číslo

3

Stát

Spojené státy americké

Strany od

270

Strany do

276

Strany počet

7

BibTex

@article{BUT103068,
  author="Miroslav {Pohanka} and Rudolf {Štětina} and Hana {Svobodová} and Branislav {Ruttkay-Nedecký} and Martina {Jílková} and Jiří {Sochor} and Jakub {Sobotka} and Vojtěch {Adam} and René {Kizek}",
  title="Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats",
  journal="DRUG AND CHEMICAL TOXICOLOGY",
  year="2013",
  volume="36",
  number="3",
  pages="270--276",
  doi="10.3109/01480545.2012.710629",
  issn="0148-0545"
}