Publication detail

Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats

POHANKA, M. ŠTĚTINA, R. SVOBODOVÁ, H. RUTTKAY-NEDECKÝ, B. JÍLKOVÁ, M. SOCHOR, J. SOBOTKA, J. ADAM, V. KIZEK, R.

Original Title

Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats

Type

journal article in Web of Science

Language

English

Original Abstract

Sulfur mustard (SM) is a chemical warfare agent with cytotoxic effect and a tight link to oxidative stress (OS). Depletion of antioxidants is considered as a cause of detrimental consequence and belongs to the important steps leading to cell death. The oxidative injury appearing after SM exposure is not well understood. Nevertheless, identification of the pathological processes would be a good opportunity to establish an efficient therapy. Here, we focused our effort on an estimation of reactive oxygen species homeostasis and apoptotic processes in Wistar rats exposed to 0-160 mg/kg of SM. We assayed antioxidant activity, thiobarbituric acid reactive substances, reduced glutathione/oxidized glutathione, metallothionein, glutathione reductase, glutathione peroxidase, glutathione S-transferase, caspase 3, and glucose in the livers, kidneys, and muscles of the animals. Significant OS, depletion of low-molecular-mass antioxidants, increase in caspase activity, and some other processes related to SM action were determined. Moreover, we infer a principal role of OS in the tested organs

Keywords

Sulfur mustard, oxidative stress, cell death

Authors

POHANKA, M.; ŠTĚTINA, R.; SVOBODOVÁ, H.; RUTTKAY-NEDECKÝ, B.; JÍLKOVÁ, M.; SOCHOR, J.; SOBOTKA, J.; ADAM, V.; KIZEK, R.

RIV year

2013

Released

1. 7. 2013

ISBN

0148-0545

Periodical

DRUG AND CHEMICAL TOXICOLOGY

Year of study

36

Number

3

State

United States of America

Pages from

270

Pages to

276

Pages count

7

BibTex

@article{BUT103068,
  author="Miroslav {Pohanka} and Rudolf {Štětina} and Hana {Svobodová} and Branislav {Ruttkay-Nedecký} and Martina {Jílková} and Jiří {Sochor} and Jakub {Sobotka} and Vojtěch {Adam} and René {Kizek}",
  title="Sulfur mustard causes oxidative stress and depletion of antioxidants in muscles, livers, and kidneys of Wistar rats",
  journal="DRUG AND CHEMICAL TOXICOLOGY",
  year="2013",
  volume="36",
  number="3",
  pages="270--276",
  doi="10.3109/01480545.2012.710629",
  issn="0148-0545"
}