Course detail

Biopolymers Properties and Applications

FCH-MAA_BPAAcad. year: 2019/2020

Introduction about biomaterial. Biopolymers (extraction from different sources, characterization. Relation between extraction process and chemical/physical properties of biopolymers. Chemical modification of biopolymers to obtain different properties/different shapes of materials. The applications of the biopolymers in different areas (medical, environmental, textile, pharmaceutics and tissue engineering applications).

Learning outcomes of the course unit

Students will improve their knowledge about the biopolymers: Extraction from different sources, characterizations and chemical modifications of biopolymers. Medical and environmental applications of biomaterials.

Prerequisites

Basic knowledge of organic technology.

Co-requisites

Not applicable.

Recommended optional programme components

Not applicable.

Recommended or required reading

Farzana Parveen, Recent Advances in Biopolymers, Elsevier, 2016, 281 (EN)
Vijay Kumar Thakur, Amar Singh Singha, Surface Modification of Biopolymers, Wiley, 2015, 448 (EN)
Alen Walton (Auth.), biopolymers, Elsevier Science,1973,610 (EN)
Gerald O. Aspinall (Auth.), Polysaccharides, Pergamon Press, 1970,242 (EN)
Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 Springer International Publishing,2015,2241 • Jean-Michel Mérillon (eds.), Polysaccharides: Bioactivity and Biotechnology, Springer International Publishing,2015,2241 (EN)
Robert H. Marchessault, François Ravenelle, and Xiao Xia Zhu (Eds.), ACS Symposium Volume 934; Polysaccharides for Drug Delivery and Pharmaceutical Applications, American Chemical Society,2006,354 (EN)

Planned learning activities and teaching methods

90 % face-to-face, 10 % distance learning

Assesment methods and criteria linked to learning outcomes

Written test /oral examination/activity participation in lectures (70/20/10)

Language of instruction

English

Work placements

Not applicable.

Course curriculum

Lecture 1: Introduction about biopolymers such as cellulose/oxycellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin, etc.... and their classifications depend on the following parameters.
 Depend on functionality (amino, carboxylic, hydroxyl, thiol, acetamide, etc….).
 Classification depend on structure (mono, di, branched, etc….).
 Depend applications such as biomedical and environmental purposes.
Lecture 2: Different extraction process of biopolymers:
 Chemically (using different chemical treatment),
 Enzymatically (using different enzymes as glucanase, cellulose, hyaluronidase),
 Mechanically (thermal/mechanical treatment).
Lecture 3: Characterization of biopolymers by different techniques and confirmation the structure by measure:
 Degree of polymerization, degree of deaceytlayion/acetylation, carboxylation, thiolation, oxidation,
 Molecular weight calculation,
 Degree of substitution on the linear or branched chains.
Lecture 4: Chemical modifications of by biopolymers:
 Amidation, esterification, graft copolymerization,
 Quaternization of biopolymers, alkylation, oxidation,
 Photo/chemical/physical cross-linking of the surface of biopolymers like chitin, chitosan, hyaluronic acids, alginate, cellulose, chitosan-glucan complex, silk fibroin, carrageenan to generate new different chemical/physical properties
Lecture 5: Preparation of different forms of biopolymers like:
 Membranes, films, fibers/ fabrics, hydrogel, powders,
 3D structure using freeze thawing, freeze-drying, precipitation,
 Casting, wet/electrospinning techniques.
Lecture 6: The medical uses of biopolymers as:
 Healing/dressing wound, cell carrier,
 Antibacterial agents and for bone/cartilage regenerations,
 Environmental application epically for waste water treatments and removing all hazard metals/organic substance.
Lecture 7: Uses of biomaterial (native/modified) in preparation/synthetization of:
 Different metal/metal oxide nanoparticles as reducing/ stabilizing/capping agents such as,
 Silver nanoparticles,
 Gold nanoparticles and zinc oxide nanoparticles,
 Titanium oxide nanoparticles and nanohydroxy apatite and their applications.
Lecture 8: The mechanisms of interactions between metal/metal oxide nanoparticles and biomaterials (native/modified):
 Stabilizing the metal/metal oxide nanoparticles
 reduction of metal/metal oxide nanoparticles using biopolymers such as cellulose/oxy-cellulose, starch, chitin, dextrin, chitosan, hyaluronic acid, alginate, chitin-glucan complex, pectin
 Prevent the aggregation and agglomeration of metal nanoparticles and,
 Preparation of nanocomposite materials.
Lecture 9: The environmental applications of biopolymers:
 Uses of biopolymers such as chitin, chitosan, cyclodextrin, cellulose and their derivatives on metals and organic material removal,
 Uses of biopolymer nanocomposite on wastewater treatments,
 biopolymer smart coating and sensors
Lecture 10: General overview of biopolymers and implantation process (internal and external applications of biopolymers).
 Biodegradable biopolymers based scaffold for bone tissue engineering,
 Biodegradable polymers based scaffold for cartilage tissue engineering,
 Biodegradable polymers based sheets for skin tissue regeneration.
Lecture 11: The chemical modification between biomaterials (native/modified) with;
 Synthetic polymers (poly-carbolactone, polyvinyl alcohol, polyethylene oxide….),
 Proteins (collagen, peptides) and their applications.

Aims

The main aim of the course is to improve the background of the students how to use the natural sources (animal/non animal) in order to obtain biopolymers and usage in different sectors of our life (medicine, agriculture, pharmaceutics, textile, drug delivery, etc……).

Classification of course in study plans

  • Programme AKREDITACE Doctoral, 1. year of study, winter semester, 0 credits, optional

  • Programme NKCP_CHM Master's

    branch NKCO_CHM , 1. year of study, winter semester, 0 credits, optional

  • Programme NPCP_CHM Master's

    branch NPCO_CHM , 1. year of study, winter semester, 0 credits, optional

  • Programme NKCP_CHM Master's

    branch NKCO_CHM , 1. year of study, summer semester, 0 credits, optional

  • Programme NPCP_CHM Master's

    branch NPCO_CHM , 1. year of study, summer semester, 0 credits, optional

  • Programme NPCP_CHM_INT Master's

    branch NPCO_CHM , 1. year of study, summer semester, 0 credits, optional
    branch NPCO_CHM , 1. year of study, winter semester, 0 credits, optional

  • Programme NPCP_CHM Master's

    branch NPCO_CHM , 2. year of study, winter semester, 0 credits, optional
    branch NPCO_CHM , 2. year of study, summer semester, 0 credits, optional

  • Programme NKCP_CHM Master's

    branch NKCO_CHM , 2. year of study, summer semester, 0 credits, optional
    branch NKCO_CHM , 2. year of study, winter semester, 0 credits, optional

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer