Czech

3

Not applicable.

This course provides students especially the ability to:

Working with laboratory equipment and measuring instruments for conventional organic syntheses.
Experience with preaparation of organic substances in the laboratory scale.
Experience with occupational safety and health in the chemical laboratory work with organic compounds.

The knowledge of basic laboratory practices and techniques (recrystallization, distillation, extraction, etc.).

Not applicable.

The course uses teaching methods in form of Laboratory exercise - 4 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

To obtain the credit, the student must:
Passing 11 jobs during the semester.
To master the theoretical principles of tasks.
Submit prepared and adjusted products.
Submit a fully developed laboratory protocols.
Successfully write test.

Students are briefed by organization of laboratory and syntheses in detail during the first lab. Safety training is also realized. Students realize at least 11 syntheses of the following:

1. ß -Nitrostyrene and 1,5-diphenylpenta-1,4-dien-3-one (reaction of carbonyl compounds)
2. 2,4-Dinitrophenol (nitration of aromatics compound)
3. Di-n-butylether (ether preaparation by dehydratation of alcohol)
4. Etylbromide and tert-butychloride (Nucleophilic substitution)
5. Anhydride of bicyclo[2.2.1]hept-2-ene-5,6-dicarboxylic acid and bicyclo[2.2.1]-hept-2-ene-5,6-dicarboxylic acid (Diels-Alder's reaction)
6. Jodnitrobenzene and 1-[(4-nitrophenyl)azo]-2-naphtol (reaktions of diazonium salts)
7. Ethyl acetate (Fischer's esterification)
8. N-Benzylidenaniline and N-benzylaniline (reactions of carbonyl compounds)
9. Phenacetine (acylation of amine and Wiliamson's reaction)
10. Benzimidazol a benzotriazol (preparation of heterocyclic comppounds)
11. 3-Nitroaniline (partial reduction of nitro compound)
12. Diphenylmethanol (preparation and reaction of Grignard reagent)

Labs at last week of the term are substitute for unqualified or sick students during the term.
Detailed manuals and literature for each task are available on https://moodle.vutbr.cz/course/view.php?id=171825

Not applicable.

The basis of the course is to enhance the adoption and expansion of basic laboratory methods and techniques (eg work at reduced temperatures, vacuum distillation, steam distillation) in the synthesis and analysis of organic compounds (determination of melting point, refractive index). Tasks are chosen so as to include the most common and most important types of chemical reactions discussed in hours organic chemistry.

Checked attendance, protocols, submission of prepared compounds and determining their properties (melting point, boiling point, index of refraction).

Not applicable.

Not applicable.

Kizlink J., Bednařík, K.: Návody pro laboratorní praktikum z organické chemie. VUT, Brno 2009. (CS)
https://www.vutbr.cz/elearning/course/view.php?id=121977 (CS)

Pazdera P., Potáček M.: Cvičení z metod organické chemie. MU, Brno 1997. (CS)
Sandler S.R., Karo W.: Sourcebook of Advanced Organic Laboratory Preparations. Academic Press, San Diego 1992. (CS)
Nováček E., Potáček M., Janků S.: Laboratorní technika ke cvičení z metod organické chemie. MU, Brno 2000. (CS)

52 hours, compulsory