English

4

Not applicable.

Laboratory equipment and glassware handling.
Synthesis of organic compounds in laboratory scale.
Health and safety at work in a chemical laboratory.

The knowledge of basic laboratory practices and techniques (recrystallization, distillation, extraction, etc.).

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Finish 10 laboratories at least, submit lab. reports and prepared compounds during the term.
Pass test(s) about practical and theoretical knowledges.

Students are briefed by organization of laboratory and syntheses in detail during the first lab. Safety training is also realized. Students realize at least 10 syntheses of the following:
1. 4-Nitroaniline
2. Ethylbromide a tert-butylchloride (2) (SN mechanism, simple distillation)
3. Ethyl acetate (3) (esterification, simple distillation)
4. Pinacol and pinacolon
5. Benziliv acid
6. Chlorobenzene(diazotation and Sandmeyer reaction, recrystallization)
7. Anhydride of cyclohex-4-ene-cis-dicarboxylic acid and Cyclohex-4-ene-cis-1,2-dicarboxylic acid (mechanism of Diels-Alder's reaction)
8. Phenacetine
9. Acid Red 150 (diazotation and copulation, recrystallization)
10. ß -Nitrostyrene (10a) a 1,5-difenylpenta-1,4-dien-3-one (10b)
11. Diphenylmethanol
12. 2-(-4-Toluoyl)benzoic acid
Labs at last week of the term are substitute for unqualified or sick students during the term.

Not applicable.

Acquisition of the basic laboratory methods of the analysis and synthesis of organic substances.

Controlled personal attendance, lab. reports a test(s).

Not applicable.

Not applicable.

Not applicable.

Sandler S.R., Karo W.: Sourcebook of Advanced Organic Laboratory Preparations. Academic Press, San Diego 1992. (EN)

78 hours, compulsory