Publication detail

Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

LÍZAL, F. JEDELSKÝ, J. ADAM, J. BĚLKA, M. JÍCHA, M.

Original Title

Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

English Title

Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs

Type

conference paper

Language

en

Original Abstract

Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.

English abstract

Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.

Keywords

aerosol transport, aerosol deposition, positron emission tomography, human lung model

RIV year

2012

Released

09.04.2013

Publisher

EPJ Web of Conferences

Location

Francie

ISBN

978-80-7372-912-7

Book

EPJ Web of Conferences

Pages from

1

Pages to

4

Pages count

4

URL

BibTex


@inproceedings{BUT95329,
  author="František {Lízal} and Jan {Jedelský} and Jan {Adam} and Miloslav {Bělka} and Miroslav {Jícha}",
  title="Application of Positron Emission Tomography to Aerosol Transport Research in a Model of Human Lungs",
  annote="Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured.",
  address="EPJ Web of Conferences",
  booktitle="EPJ Web of Conferences",
  chapter="95329",
  doi="10.1051/epjconf/20134501060",
  howpublished="online",
  institution="EPJ Web of Conferences",
  number="01060",
  year="2013",
  month="april",
  pages="1--4",
  publisher="EPJ Web of Conferences",
  type="conference paper"
}