Publication detail

Similarity analysis of primary and secondary structures of metallothioneins

ŠKUTKOVÁ, H. PROVAZNÍK, I. KIZEK, R.

Original Title

Similarity analysis of primary and secondary structures of metallothioneins

English Title

Similarity analysis of primary and secondary structures of metallothioneins

Type

conference paper

Language

en

Original Abstract

Metallothioneins (MTs) are small cysteine-rich proteins that are involved in many diverse biological processes, which are interesting especially due to their influence on therapy of cancer. The primary structures of MTs from different organisms are various despite they have the same purpose - a transport of metal ions in organisms. Every single mutation in amino acid sequences can have a drastic effect to secondary structures thereby on MTs function. This study presents dependence of diversity of primary and secondary structures on function of MTs.

English abstract

Metallothioneins (MTs) are small cysteine-rich proteins that are involved in many diverse biological processes, which are interesting especially due to their influence on therapy of cancer. The primary structures of MTs from different organisms are various despite they have the same purpose - a transport of metal ions in organisms. Every single mutation in amino acid sequences can have a drastic effect to secondary structures thereby on MTs function. This study presents dependence of diversity of primary and secondary structures on function of MTs.

Keywords

phylogentic tree, neigbour-joining, BIONJ, Jukes-Cantor, metallothionein, isoforms, phylogenetic network, NeighborNet, metal ions

RIV year

2010

Released

02.11.2010

Publisher

IEEE

Location

Corfu

ISBN

978-1-4244-6560-6

Book

The 10th IEEE International Conference on Information Technology and Applications in Biomedicine: Emerging Technologies for Patient Specific Healthcare

Edition number

10

Pages from

1

Pages to

4

Pages count

4

BibTex


@inproceedings{BUT34568,
  author="Helena {Škutková} and Ivo {Provazník} and René {Kizek}",
  title="Similarity analysis of primary and secondary structures of metallothioneins",
  annote="Metallothioneins (MTs) are small cysteine-rich proteins that are involved in many diverse biological processes, which are interesting especially due to their influence on therapy of cancer. The primary structures of MTs from different organisms are various despite they have the same purpose - a transport of metal ions in organisms.  Every single mutation in amino acid sequences can have a drastic effect to secondary structures thereby on MTs function. This study presents dependence of diversity of primary and secondary structures on function of MTs.",
  address="IEEE",
  booktitle="The 10th IEEE International Conference on Information Technology and Applications in Biomedicine: Emerging Technologies for Patient Specific Healthcare",
  chapter="34568",
  howpublished="electronic, physical medium",
  institution="IEEE",
  year="2010",
  month="november",
  pages="1--4",
  publisher="IEEE",
  type="conference paper"
}