Publication detail

TENSEGRITY STRUCTURES AND THEIR APPLICATION IN MODELS OF CYTOSKELETON

BURŠA, J.

Original Title

TENSEGRITY STRUCTURES AND THEIR APPLICATION IN MODELS OF CYTOSKELETON

English Title

TENSEGRITY STRUCTURES AND THEIR APPLICATION IN MODELS OF CYTOSKELETON

Type

conference paper

Language

en

Original Abstract

Investigation of principles of mechanotransduction in living animal cells creates a basis for understanding processes in cardio-vascular system such as tissue remodelation, atherosclerotic changes, growth of aneurysms, etc. To be able to estimate the biochemical response of the cell or tissue on a mechanical load, we need to determinate the very quantity (or set of quantities) that is responsible for this response. As cell is a complex structure with numerous components, it cannot be expected that this quantity will be found on the base of homogeneous continuum models. Therefore more complex (structural) finite element models of the mechanical behaviour of cells are needed. A new more realistic model of cytoskeleton has been created. The model should be able to simulate various mechanical tests of isolated cells. In future various types of tests carried out with the same type of cells (vascular smooth muscle cells) should be simulated with the aim to identify constitutive parameters of the individual components of the model.

English abstract

Investigation of principles of mechanotransduction in living animal cells creates a basis for understanding processes in cardio-vascular system such as tissue remodelation, atherosclerotic changes, growth of aneurysms, etc. To be able to estimate the biochemical response of the cell or tissue on a mechanical load, we need to determinate the very quantity (or set of quantities) that is responsible for this response. As cell is a complex structure with numerous components, it cannot be expected that this quantity will be found on the base of homogeneous continuum models. Therefore more complex (structural) finite element models of the mechanical behaviour of cells are needed. A new more realistic model of cytoskeleton has been created. The model should be able to simulate various mechanical tests of isolated cells. In future various types of tests carried out with the same type of cells (vascular smooth muscle cells) should be simulated with the aim to identify constitutive parameters of the individual components of the model.

Keywords

Keywords: Tensegrity, cytoskeleton, mechanotransduction, finite element model

RIV year

2006

Released

13.11.2006

Publisher

Brno University of Technology, Institute of Solid mechanics, Mechatronics and Biomechanics

Location

Hrotovice

ISBN

80-214-3232-2

Book

Human Biomechanics 2006

Pages from

68

Pages to

69

Pages count

8

Documents

BibTex


@inproceedings{BUT24562,
  author="Jiří {Burša}",
  title="TENSEGRITY STRUCTURES AND THEIR APPLICATION IN MODELS OF CYTOSKELETON",
  annote="Investigation of principles of mechanotransduction in living animal cells creates a basis for understanding processes in cardio-vascular system such as tissue remodelation, atherosclerotic changes, growth of aneurysms, etc. To be able to estimate the biochemical response of the cell or tissue on a mechanical load, we need to determinate the very quantity (or set of quantities) that is responsible for this response. As cell is a complex structure with numerous components, it cannot be expected that this quantity will be found on the base of homogeneous continuum models. Therefore more complex (structural) finite element models of the mechanical behaviour of cells are needed.
A new more realistic model of cytoskeleton has been created. The model should be able to simulate various mechanical tests of isolated cells. In future various types of tests carried out with the same type of cells (vascular smooth muscle cells)  should be simulated with the aim to identify constitutive parameters of the individual components of the model.",
  address="Brno University of Technology, Institute of Solid mechanics, Mechatronics and Biomechanics",
  booktitle="Human Biomechanics 2006",
  chapter="24562",
  institution="Brno University of Technology, Institute of Solid mechanics, Mechatronics and Biomechanics",
  journal="Nezařazené články",
  year="2006",
  month="november",
  pages="68--69",
  publisher="Brno University of Technology, Institute of Solid mechanics, Mechatronics and Biomechanics",
  type="conference paper"
}