Publication detail

Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion

MUÑOZ MARTIN, J. OLIVER DE LA CRUZ, J. FORTE, G. PUMERA, M.

Original Title

Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion

Type

journal article in Web of Science

Language

English

Original Abstract

This work examines the suitability of graphene-based 3D-printed nanocomposite bioelectronics as innovative systems to in situ monitor and evaluate both breast cancer cell adhesion and the chemosensitivity of anti-cancer drugs. With this aim, 3D-printed nanocomposite graphene electrodes (3D-nGEs) -made of a commercially available graphene/polylactic acid filament- have been covalently biofunctionalized with an extracellular matrix protein (i.e., fibronectin) by exploiting the carbon reactivity of 3D-nGEs. The specificity and selectivity of the developed electrochemical system to monitor breast cancer cell adhesion has been tested via electrochemical impedance spectroscopy (EIS). Importantly, the resulting 3D-printed bioelectronic system displayed excellent accuracy for the rapid screening of anti-cancer drugs, which exactly corresponded with the results achieved by the standard optical method, while having the advantage of employing a label-free approach. In light of the current state-of-the-art in the field, this proof-of-concept connects electronics to biological systems within 3D printing technology, providing the bases for the sustainable and cost-effective manufacturing of graphene-based 3D-printed nanocomposite bioelectronics to simulate in vivo microenvironments using in situ and real time electronic output signals.

Keywords

3D-printed electrodes; Breast cancer cells; Electrochemical impedance spectroscopy; Anti -cancer drugs; Additive manufacturing

Authors

MUÑOZ MARTIN, J.; OLIVER DE LA CRUZ, J.; FORTE, G.; PUMERA, M.

Released

15. 4. 2023

Publisher

ELSEVIER ADVANCED TECHNOLOGY

Location

OXFORD

ISBN

1873-4235

Periodical

BIOSENSORS & BIOELECTRONICS

Year of study

226

Number

115113

State

Kingdom of the Netherlands

Pages count

8

URL

https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556

BibTex

@article{BUT186926,
  author="Jose Maria {Muñoz Martin} and Jorge {Oliver De La Cruz} and Giancarlo {Forte} and Martin {Pumera}",
  title="Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion",
  journal="BIOSENSORS & BIOELECTRONICS",
  year="2023",
  volume="226",
  number="115113",
  pages="8",
  doi="10.1016/j.bios.2023.115113",
  issn="1873-4235",
  url="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556"
}