Publication detail

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Petersen, J. Englmaier, L. Artemov, A.V. Poverennaya, I Mahmoud, R. Bouderlique, T. Tesarova, M. Deviatiiarov, R. Szilvásy-Szabó, A. Akkuratov, E.E. Reguera, D.P. Zeberg, H. Kaucka, M. Kastriti, M.E. Krivanek, J. Radaszkiewicz, T. Gömöryová, K. Knauth, S. Potesil, D. Zdrahal, Z. Sri Ganji, R. Grabowski, A. Buhl, M.E. Zikmund, T. Kavkova, M. Axelson, H. Lindgren, D. Kramann, D. Kuppe, C. Erdélyi, F. Máté, Z. Szabó, G. Koehne, T. Harkany, T. Fried, K. et al.

Original Title

A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Type

journal article in Web of Science

Language

English

Original Abstract

In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.

Keywords

FAME, Evolutionary genetics, Genetic models, Kidney

Authors

Petersen, J.; Englmaier, L.; Artemov, A.V.; Poverennaya, I; Mahmoud, R.; Bouderlique, T.; Tesarova, M.; Deviatiiarov, R.; Szilvásy-Szabó, A.; Akkuratov, E.E.; Reguera, D.P.; Zeberg, H.; Kaucka, M.; Kastriti, M.E.; Krivanek, J.; Radaszkiewicz, T.; Gömöryová, K.; Knauth, S.; Potesil, D.; Zdrahal, Z.; Sri Ganji, R.; Grabowski, A.; Buhl, M.E.; Zikmund, T.; Kavkova, M.; Axelson, H.; Lindgren, D.; Kramann, D.; Kuppe, C.; Erdélyi, F.; Máté, Z.; Szabó, G.; Koehne, T.; Harkany, T.; Fried, K. et al.

Released

29. 5. 2023

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2041-1723

Periodical

NATURE COMMUNICATIONS

Year of study

14

Number

3092

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

22

Pages count

22

URL

https://www.nature.com/articles/s41467-023-38663-7

Full text in the Digital Library

http://hdl.handle.net/11012/214444

BibTex

@article{BUT185232,
  author="Petersen, J. and Englmaier, L. and Artemov, A.V. and Poverennaya, I and Mahmoud, R. and Bouderlique, T. and Tesarova, M. and Deviatiiarov, R. and Szilvásy-Szabó, A. and Akkuratov, E.E. and Reguera, D.P. and Zeberg, H. and Kaucka, M. and Kastriti, M.E. and Krivanek, J. and Radaszkiewicz, T. and Gömöryová, K. and Knauth, S. and Potesil, D. and Zdrahal, Z. and Sri Ganji, R. and Grabowski, A. and Buhl, M.E. and Zikmund, T. and Kavkova, M. and Axelson, H. and Lindgren, D. and Kramann, D. and Kuppe, C. and Erdélyi, F. and Máté, Z. and Szabó, G. and Koehne, T. and Harkany, T. and Fried, K. et al.",
  title="A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology",
  journal="NATURE COMMUNICATIONS",
  year="2023",
  volume="14",
  number="3092",
  pages="1--22",
  doi="10.1038/s41467-023-38663-7",
  issn="2041-1723",
  url="https://www.nature.com/articles/s41467-023-38663-7"
}