Publication detail

Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid

DUBAIC M., PESKOVA L., HAMPL M., WEISSOVA K., CELIKER C., SHYLO N., HRUBA E., KAVKOVA M., ZIKMUND T., WEATHERBOO S., KAISER J., BARTA T., BUCHTOVA M.

Original Title

Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid

Type

journal article in Web of Science

Language

English

Original Abstract

Primary cilia, enriched in receptors and signaling molecules, serve as vital signaling hubs responsive to stimuli and are implicated in human diseases like retinopathies. TMEM107, localized to the transition zone of primary cilia, is linked to conditions such as Joubert and Meckel–Gruber syndromes, and its deficiency hinders cilia formation and early vertebrate eye development in retinal organoids.

Keywords

TMEM107, ciliopathy, eye development, cell biology

Authors

DUBAIC M., PESKOVA L., HAMPL M., WEISSOVA K., CELIKER C., SHYLO N., HRUBA E., KAVKOVA M., ZIKMUND T., WEATHERBOO S., KAISER J., BARTA T., BUCHTOVA M.

Released

20. 10. 2023

Publisher

Life Science Alliance

ISBN

2575-1077

Periodical

Life Science Alliance

Year of study

6

Number

12

State

United States of America

Pages from

1

Pages to

16

Pages count

16

URL

https://www.life-science-alliance.org/content/6/12/e202302073

Full text in the Digital Library

http://hdl.handle.net/11012/245089

BibTex

@article{BUT184959,
  author="Marija {Dubaic} and Lucie {Pešková} and Marek {Hampl} and Kamila {Weissová} and Canan {Celiker} and Natalya A. {Shylo} and Eva {Hrubá} and Michaela {Kavková} and Tomáš {Zikmund} and Scott Donald {Weatherbee} and Jozef {Kaiser} and Tomáš {Bárta} and Marcela {Buchtová}",
  title="Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid",
  journal="Life Science Alliance",
  year="2023",
  volume="6",
  number="12",
  pages="1--16",
  doi="10.26508/lsa.202302073",
  issn="2575-1077",
  url="https://www.life-science-alliance.org/content/6/12/e202302073"
}