Publication detail

IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

JAGOŠ, J. KOHÚT, J. NOVOTNÝ, T. KŘIVKA, T. HÁJEK, P. FORMÁNEK, M. BURŠA, J.

Original Title

IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

Type

article in a collection out of WoS and Scopus

Language

English

Original Abstract

Although preventable, hypertension and hypertensive renal disease remain one of the major global risk factors for cardiovascular diseases, especially in the developed world [1]. Hypertension is defined as a chronically increased blood pressure (BP) above 140/90 mmHg and is related to an increase in peripheral resistance and decrease in arterial distensibility [2], similarly to an aging [1]. Available evidence confirms the ability of all five basic groups of antihypertensives to decrease arterial stiffness and consequently the BP in the long-term application [3]. Although proper treatment of hypertension attenuates its influence, the mechanisms by which hypertension accelerates atherosclerosis are poorly understood [4]. It is known that flow waveform for older subjects differs substantially from the young one mainly due to elevated arterial stiffness and consequently early wave reflection [5]. Moreover, the decreasing arterial stiffness via proper treatment of hypertension shifts the shape of the flow waveform to a young and healthy one [6]. Since arterial stiffness can be lowered through long-term application of antihypertensives, benefits of medical therapy could be not only in lowering the BP and peripheral resistance but also in improving the hemodynamic conditions.

Keywords

HEMODYNAMICAL SIMULATIONS; ANTIHYPERTENSIVE DRUGS

Authors

JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; BURŠA, J.

Released

9. 7. 2023

Location

Maastricht

Pages count

1

URL

https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf

BibTex

@inproceedings{BUT184917,
  author="Jiří {Jagoš} and Jiří {Kohút} and Tomáš {Novotný} and Tomáš {Křivka} and Petr {Hájek} and Martin {Formánek} and Jiří {Burša}",
  title="IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS",
  booktitle="ESB 2023 BOOK OF ABSTRACTS",
  year="2023",
  number="28",
  pages="1",
  address="Maastricht",
  url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf"
}