Publication detail

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

ČERNOHLÁVEK, M. BRANDEJSOVÁ, M. ŠTĚPÁN, P. VÁGNEROVÁ, H. HERMANNOVÁ, M. KOPECKÁ, K. KULHÁNEK, J. NEČAS, D. VRBKA, M. VELEBNÝ, V. ANGELES, G.

Original Title

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

Type

journal article in Web of Science

Language

English

Original Abstract

Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease. High and low molecular weight HA are currently used in ophthalmology. However, a large portion of the current literature on friction and lubrication addresses articular (joint) cartilage. Therefore, eye drops compositions based on HA and its derivatized forms are extensively characterized providing data on the tribological and mucoadhesive properties. The physiochemical properties are investigated in buffers used commonly in eye drops formulations. The tribological investigation reveals that amphiphilic HA-C12 decreases the friction coefficient. At the same time, the combination of trehalose/HA or HAC12 enhances up to eighty-fold the mucoadhesiveness. Thus, it is predicted a prolonged residence time on the surface of the eye. The incorporation of trehalose enhances the protection of human keratinocytes (HaCaT) cells, as demonstrated in an in-vitro cell-desiccation model. The presence of trehalose increases the friction coefficient. Medium molecular weight HA shows significantly lower friction coefficient than high molecular weight HA. This research represents a first, wide array of features of diverse HA forms for eye drops contributing to increase the knowledge of these preparations. The results here presented also provide valuable information for the design of highly performing HA-formulations addressing specific needs before preclinic.

Keywords

hyaluronan; biotribology; friction; lubrication; eye drops

Authors

ČERNOHLÁVEK, M.; BRANDEJSOVÁ, M.; ŠTĚPÁN, P.; VÁGNEROVÁ, H.; HERMANNOVÁ, M.; KOPECKÁ, K.; KULHÁNEK, J.; NEČAS, D.; VRBKA, M.; VELEBNÝ, V.; ANGELES, G.

Released

30. 9. 2021

Publisher

MDPI

Location

Basilej, Švýcarsko

ISBN

2218-273X

Periodical

Biomolecules

Year of study

11

Number

10

State

Swiss Confederation

Pages from

1431

Pages to

1431

Pages count

15

URL

https://www.mdpi.com/2218-273X/11/10/1431/htm

Full text in the Digital Library

http://hdl.handle.net/11012/203067

BibTex

@article{BUT173155,
  author="Mikuláš {Černohlávek} and Martina {Brandejsová} and Petr {Štěpán} and Hana {Vágnerová} and Martina {Hermannová} and Kateřina {Kopecká} and Jaromír {Kulhánek} and David {Nečas} and Martin {Vrbka} and Vladimír {Velebný} and Gloria Huerta {Angeles}",
  title="Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery",
  journal="Biomolecules",
  year="2021",
  volume="11",
  number="10",
  pages="1431--1431",
  doi="10.3390/biom11101431",
  issn="2218-273X",
  url="https://www.mdpi.com/2218-273X/11/10/1431/htm"
}