Publication detail

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

KAUCKÁ, M. SZAROWSKÁ, B. KAVKOVÁ, M. KASTRITI, M. KAMENEVA, P. SCHMIDT, I. PEŠKOVÁ, L. JOVEN ARAUS, A. SIMON, A. KAISER, J. ADAMEYKO, I.

Original Title

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

Type

journal article in Web of Science

Language

English

Original Abstract

Melanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.

Keywords

Extracutaneous pigment cell;Targeted recruitment;Endothelin 3 and endothelin receptor B;Glial precursor;Peripheral nerves;Hypopigmentation-associated deafness

Authors

KAUCKÁ, M.; SZAROWSKÁ, B.; KAVKOVÁ, M.; KASTRITI, M.; KAMENEVA, P.; SCHMIDT, I.; PEŠKOVÁ, L.; JOVEN ARAUS, A.; SIMON, A.; KAISER, J.; ADAMEYKO, I.

Released

18. 7. 2021

Publisher

Springer

ISBN

1420-9071

Periodical

Cellular and Molecular Life Sciences

Year of study

78

Number

14

State

Swiss Confederation

Pages from

6033

Pages to

6049

Pages count

17

URL

https://link.springer.com/article/10.1007%2Fs00018-021-03885-9

Full text in the Digital Library

http://hdl.handle.net/11012/203036

BibTex

@article{BUT172051,
  author="Markéta {Kaucká} and Bára {Szarowská} and Michaela {Kavková} and Maria Eleni {Kastriti} and Polina {Kameneva} and Inga {Schmidt} and Lucie {Pešková} and Alberto {Joven Araus} and Andras {Simon} and Jozef {Kaiser} and Igor {Adameyko}",
  title="Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges",
  journal="Cellular and Molecular Life Sciences",
  year="2021",
  volume="78",
  number="14",
  pages="6033--6049",
  doi="10.1007/s00018-021-03885-9",
  issn="1420-9071",
  url="https://link.springer.com/article/10.1007%2Fs00018-021-03885-9"
}