Publication detail

Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. BRÁZDA, V.

Original Title

Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

Type

journal article in Web of Science

Language

English

Original Abstract

The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.

Keywords

Bioinformatics; Coevolution; DsDNA; G-quadruplex; G4Hunter; Host; Virus

Authors

BOHÁLOVÁ, N.; CANTARA, A.; BARTAS, M.; KAURA, P.; ŠŤASTNÝ, J.; PEČINKA, P.; FOJTA, M.; BRÁZDA, V.

Released

1. 4. 2021

Publisher

MDPI

ISBN

1422-0067

Periodical

International Journal of Molecular Sciences

Year of study

22

Number

7

State

Swiss Confederation

Pages from

1

Pages to

12

Pages count

12

URL

https://www.mdpi.com/1422-0067/22/7/3433

Full text in the Digital Library

http://hdl.handle.net/11012/200878

BibTex

@article{BUT171724,
  author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Václav {Brázda}",
  title="Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences",
  journal="International Journal of Molecular Sciences",
  year="2021",
  volume="22",
  number="7",
  pages="1--12",
  doi="10.3390/ijms22073433",
  issn="1422-0067",
  url="https://www.mdpi.com/1422-0067/22/7/3433"
}