Increased late graft loss in kidney recipients with serum sickness disease following anti-thymocyte globulin induction: relation with an anti-NEU5GC response

abstract

English

Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc antibodies in human serum. However, Neu5Gc is expressed on mammal glycoproteins and glycolipids in most organs and cells. We review here the relevance of Neu5Gc and anti-Neu5Gc antibodies in the context of xenotransplantation and the use of animal-derived molecules and products, as well as the possible consequences of a long-term exposure to anti-Neu5Gc antibodies in recipients of xenografts. In addition, the importance of an accurate estimation of the anti-Neu5Gc response following xenotransplantation and the future contribution of knockout animals mimicking the human situation are also assessed

kidney, globulin

Salama, A.; Couvrat-Desvergnes, G.; Le Berre, L.; Evanno, G.; Viklicky, O.; Hruba, P.; Vesely, P.; Guerif, P.; Dejoie, T.; Nicot, AB.; Bach, JM.; Brouard, S.; Castagnet, S.; Giral, M.; Harb, J.; Foucher, Y.; Lorent, M.; Soulillou, JP.

1. 11. 2015

0908-665X

XENOTRANSPLANTATION

22

1

Kingdom of Denmark

S85

S86

2