Publication detail

Hydrogels based on cationic polyelectrolytes

JARÁBKOVÁ, S. MRAVEC, F. SMILEK, J. PEKAŘ, M.

Original Title

Hydrogels based on cationic polyelectrolytes

English Title

Hydrogels based on cationic polyelectrolytes

Type

conference paper

Language

en

Original Abstract

The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.

English abstract

The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.

Keywords

hydrogel, polyelectrolyte, surfactant, nanodomain, micelles, rheology, solubilization test

Released

23.03.2017

Publisher

Vysoké učení technické v Brně, Fakulta chemická

Location

Brno

ISBN

978-80-214-5489-7

Book

Sborník příspěvků

Edition

1.

Edition number

první

Pages from

194

Pages to

197

Pages count

4

BibTex


@inproceedings{BUT138705,
  author="Sabína {Jarábková} and Filip {Mravec} and Jiří {Smilek} and Miloslav {Pekař}",
  title="Hydrogels based on cationic polyelectrolytes",
  annote="The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.",
  address="Vysoké učení technické v Brně, Fakulta chemická",
  booktitle="Sborník příspěvků",
  chapter="138705",
  edition="1.",
  howpublished="electronic, physical medium",
  institution="Vysoké učení technické v Brně, Fakulta chemická",
  year="2017",
  month="march",
  pages="194--197",
  publisher="Vysoké učení technické v Brně, Fakulta chemická",
  type="conference paper"
}