Publication detail

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

LÍZAL, F. BĚLKA, M. ADAM, J. JEDELSKÝ, J. JÍCHA, M.

Original Title

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

English Title

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

Type

journal article in Web of Science

Language

en

Original Abstract

This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography–computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.

English abstract

This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography–computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.

Keywords

positro emission tomography, aerosol, aerosol deposition, targeted drug delivery

RIV year

2015

Released

01.10.2015

Publisher

SAGE Publications

Location

London, UK

Pages from

750

Pages to

757

Pages count

8

BibTex


@article{BUT117312,
  author="František {Lízal} and Miloslav {Bělka} and Jan {Adam} and Jan {Jedelský} and Miroslav {Jícha}",
  title="A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography",
  annote="This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography–computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity
analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.",
  address="SAGE Publications",
  chapter="117312",
  doi="10.1177/0954411915600005",
  howpublished="print",
  institution="SAGE Publications",
  number="10",
  volume="229",
  year="2015",
  month="october",
  pages="750--757",
  publisher="SAGE Publications",
  type="journal article in Web of Science"
}