Publication detail

A new approach to characterization of ultrasound contrast agents

PILGROVÁ, T. MRAVEC, F. POSPÍŠILOVÁ, Z. ORBAN, M. PEKAŘ, M.

Original Title

A new approach to characterization of ultrasound contrast agents

English Title

A new approach to characterization of ultrasound contrast agents

Type

abstract

Language

en

Original Abstract

Microbubbles are used as contrast agents in combination with ultrasound and currently are proposed for drug delivery applications. For this development is necessary to identify a microbubble formation process and stability of the system. In this respect new physico-chemical approach to characterization of SonoVue® microbubbles and phospholipid systems was found. Basic properties of these systems such as size distribution, zeta potential and phase stability of particles or solubilization ability were studied using spectroscopic methods because of behavior in biological system. Selected solutes, which could serve as a model substances at the use of these systems for theranostic applications were investigated. Other phospholipids and surfactants were compared with SonoVue® for evaluation of effect of system composition on final properties of the system. It was found that surface properties of phospholipid systems are significant for microbubble formation and stability of contrast agents. Observed behavior of studied phospholipids systems comes up with the goods and it was confirmed that studied systems are able to solubilize hydrophobic solutes in their structure. This could be utilized in drug delivery applications. We present results of a study of colloid properties of ultrasound contrast agents. Selected techniques and characterization methods are very useful for study surface properties and formation process of ultrasound contrast agents.

English abstract

Microbubbles are used as contrast agents in combination with ultrasound and currently are proposed for drug delivery applications. For this development is necessary to identify a microbubble formation process and stability of the system. In this respect new physico-chemical approach to characterization of SonoVue® microbubbles and phospholipid systems was found. Basic properties of these systems such as size distribution, zeta potential and phase stability of particles or solubilization ability were studied using spectroscopic methods because of behavior in biological system. Selected solutes, which could serve as a model substances at the use of these systems for theranostic applications were investigated. Other phospholipids and surfactants were compared with SonoVue® for evaluation of effect of system composition on final properties of the system. It was found that surface properties of phospholipid systems are significant for microbubble formation and stability of contrast agents. Observed behavior of studied phospholipids systems comes up with the goods and it was confirmed that studied systems are able to solubilize hydrophobic solutes in their structure. This could be utilized in drug delivery applications. We present results of a study of colloid properties of ultrasound contrast agents. Selected techniques and characterization methods are very useful for study surface properties and formation process of ultrasound contrast agents.

Keywords

microbubbles, ultrasound, drug delivery, spectroscopy

Released

10.09.2015

Location

Brno

Pages from

62

Pages to

62

Pages count

1

Documents

BibTex


@misc{BUT116316,
  author="Tereza {Pilgrová} and Filip {Mravec} and Zdenka {Pospíšilová} and Marek {Orban} and Miloslav {Pekař}",
  title="A new approach to characterization of ultrasound contrast agents",
  annote="Microbubbles are used as contrast agents in combination with ultrasound and currently are proposed for drug delivery applications. For this development is necessary to identify a microbubble formation process and stability of the system. In this respect new physico-chemical approach to characterization of SonoVue® microbubbles and phospholipid systems was found. Basic properties of these systems such as size distribution, zeta potential and phase stability of particles or solubilization ability were studied using spectroscopic methods because of behavior in biological system. Selected solutes, which could serve as a model substances at the use of these systems for theranostic applications were investigated. Other phospholipids and surfactants were compared with SonoVue® for evaluation of effect of system composition on final properties of the system.

It was found that surface properties of phospholipid systems are significant for microbubble formation and stability of contrast agents. Observed behavior of studied phospholipids systems comes up with the goods and it was confirmed that studied systems are able to solubilize hydrophobic solutes in their structure. This could be utilized in drug delivery applications. 
 
We present results of a study of colloid properties of ultrasound contrast agents. Selected techniques and characterization methods are very useful for study surface properties and formation process of ultrasound contrast agents.
",
  booktitle="SMIT 2015  - Abstract Book",
  chapter="116316",
  howpublished="print",
  year="2015",
  month="september",
  pages="62",
  type="abstract"
}