Publication detail

Models of Living Cells on the Basis of Tensegrity Structures.

BURŠA, J. BANSOD, Y.

Original Title

Models of Living Cells on the Basis of Tensegrity Structures.

English Title

Models of Living Cells on the Basis of Tensegrity Structures.

Type

conference paper

Language

en

Original Abstract

Applications of tensegrity principle for modelling of cytoskeleton of living cells is described in another related paper by the same authors. Here an overview of computational models of mechanical behaviour of whole cells is presented, from the simplest continuous ones up to hybrid models, and their advantages and drawbacks are analysed. In hybrid models, discrete tensegrity models of cytoskeleton are combined with continuum models of cytoplasm, nucleus and cell membrane to create prestressed finite element models of eukaryotic cells. Results obtained at various levels of complexity of the tensegrity structure are presented and compared. These models are capable to simulate different mechanical tests with isolated cells; they should be capable to simulate the transmission of mechanical stimuli from the extracellular medium (exoskeleton) onto the controlling organelles inside the cell (nucleus and/or centrosome) and in this way to contribute to understanding of mechanotransduction process in these cells.

English abstract

Applications of tensegrity principle for modelling of cytoskeleton of living cells is described in another related paper by the same authors. Here an overview of computational models of mechanical behaviour of whole cells is presented, from the simplest continuous ones up to hybrid models, and their advantages and drawbacks are analysed. In hybrid models, discrete tensegrity models of cytoskeleton are combined with continuum models of cytoplasm, nucleus and cell membrane to create prestressed finite element models of eukaryotic cells. Results obtained at various levels of complexity of the tensegrity structure are presented and compared. These models are capable to simulate different mechanical tests with isolated cells; they should be capable to simulate the transmission of mechanical stimuli from the extracellular medium (exoskeleton) onto the controlling organelles inside the cell (nucleus and/or centrosome) and in this way to contribute to understanding of mechanotransduction process in these cells.

Keywords

Cell mechanics, computational models, continuum approach, mechanical models

RIV year

2014

Released

15.07.2014

Publisher

6th World Conference on Structural Control and Monitoring (6WCSCM).

Location

Barcelona, Spain.

ISBN

978-84-942844-5-8

Book

6th World Conference on Structural Contral and Monitoring.

Pages from

140

Pages to

146

Pages count

7

Documents

BibTex


@inproceedings{BUT116022,
  author="Yogesh Deepak {Bansod} and Jiří {Burša}",
  title="Models of Living Cells on the Basis of Tensegrity Structures.",
  annote="Applications of tensegrity principle for modelling of cytoskeleton of living cells is described in another related paper by the same authors. Here an overview of computational models of mechanical behaviour of whole cells is presented, from the simplest continuous ones up to hybrid models, and their advantages and drawbacks are analysed. In hybrid models, discrete tensegrity models of cytoskeleton are combined with continuum models of cytoplasm, nucleus and cell membrane to create prestressed finite element models of eukaryotic cells. Results obtained at various levels of complexity of the tensegrity structure are presented and compared. These models are capable to simulate different mechanical tests with isolated cells; they should be capable to simulate the transmission of mechanical stimuli from the extracellular medium (exoskeleton) onto the controlling organelles
inside the cell (nucleus and/or centrosome) and in this way to contribute to understanding of mechanotransduction process in these cells.",
  address="6th World Conference on Structural Control and Monitoring (6WCSCM).",
  booktitle="6th World Conference on Structural Contral and Monitoring.",
  chapter="116022",
  howpublished="electronic, physical medium",
  institution="6th World Conference on Structural Control and Monitoring (6WCSCM).",
  year="2014",
  month="july",
  pages="140--146",
  publisher="6th World Conference on Structural Control and Monitoring (6WCSCM).",
  type="conference paper"
}