Publication detail

The Effect of Cadmium Ions and Cadmium Nanoparticles on Chicken Embryos and Evaluation of Organ Accumulation

KENŠOVÁ, R. BLAŽKOVÁ, I. VACULOVIČOVÁ, M. MILOSAVLJEVIĆ, V. BLAŽKOVÁ, L. HYNEK, D. KOPEL, P. NOVOTNÁ, M. ZEHNÁLEK, J. POHANKA, M. TRNKOVÁ, L. ADAM, V. KIZEK, R.

Original Title

The Effect of Cadmium Ions and Cadmium Nanoparticles on Chicken Embryos and Evaluation of Organ Accumulation

Type

journal article in Web of Science

Language

English

Original Abstract

The presence of metals in the organism has both positive and negative influence on the functions of the body, depending on the concentration. Cadmium is one of the metals that have irrefutable negative effect. It is highly toxic metal with long biological half-life causing damage of kidneys, bones and has carcinogenic effect. The aim of this work was the study of the effect and distribution of the cadmium in the body and its comparison with cadmium nanoparticles – CdTe quantum dots (QDs). Model organism for these experiments was chicken embryo in 16th developmental day. The distribution of cadmium was analyzed after the application of 500 uL of cadmium solution (Cd ions) in concentration 1 mg/mL or 4.5 mg/mL). This solution was applied through the small hole in the egg shell onto the chorioallantoic membrane. After 24 hours of the incubation (37.5 C, 45% rH) liver, kidney, brain and hearth were extracted. The concentration of cadmium was analyzed after the mineralization of the samples by atomic absorption spectrometry and differential pulse voltammetry. The toxicity of cadmium solution was significantly higher compared to the solution of QDs. Embryos exposed to the cadmium ions exhibited 100% mortality after 24 hours. On the contrary, the mortality of embryos exposed to QDs was 0%. The highest levels of cadmium were detected in the kidneys (125 ug per g) and in the liver (107 ug per g).

Keywords

Cadmium; Quantum Dots; Chicken embryos; Tissue; Distribution; Atomic absorption spectroscopy; Differential pulse voltammetry

Authors

KENŠOVÁ, R.; BLAŽKOVÁ, I.; VACULOVIČOVÁ, M.; MILOSAVLJEVIĆ, V.; BLAŽKOVÁ, L.; HYNEK, D.; KOPEL, P.; NOVOTNÁ, M.; ZEHNÁLEK, J.; POHANKA, M.; TRNKOVÁ, L.; ADAM, V.; KIZEK, R.

RIV year

2015

Released

1. 4. 2015

Publisher

ESG

ISBN

1452-3981

Periodical

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Year of study

10

Number

4

State

Republic of Serbia

Pages from

3623

Pages to

3634

Pages count

12

URL

http://www.electrochemsci.org/papers/vol10/100403623.pdf

Full text in the Digital Library

http://hdl.handle.net/11012/201453

BibTex

@article{BUT114334,
  author="Renáta {Kenšová} and Iva {Blažková} and Markéta {Vaculovičová} and Vedran {Milosavljević} and Lucie {Blažková} and David {Hynek} and Pavel {Kopel} and Marie {Novotná} and Josef {Zehnálek} and Miroslav {Pohanka} and Libuše {Trnková} and Vojtěch {Adam} and René {Kizek}",
  title="The Effect of Cadmium Ions and Cadmium Nanoparticles on Chicken Embryos and Evaluation of Organ Accumulation",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2015",
  volume="10",
  number="4",
  pages="3623--3634",
  issn="1452-3981",
  url="http://www.electrochemsci.org/papers/vol10/100403623.pdf"
}