Publication detail

Mechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig model

FEDOROVÁ, P. SRNEC, R. PĚNČÍK, J. SCHMID, P. AMLER, E. URBANOVÁ, L. NEČAS, A.

Original Title

Mechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig model

English Title

Mechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig model

Type

journal article in Web of Science

Language

en

Original Abstract

The study deals with mechanical testing of newly developed material polyethylene terephtalate coated with polycaprolactone nanofibers in combination with biodagradable Hexalon ACL/PCL screws as a new possibility of intra-articular reinforcement of partially ruptured cranial cruciate ligament. Four groups of ex vivo models of pig stifle joints were prepared and tested: a model with intact CCL (group 1), a model with partial CCL rupture (group 2), a model with CCL rupture stabilized with 7 mm Mersilene strip (group 3), and a model with CCL rupture stabilized with 5 mm PET/PCL biomaterial strip (group 4). The models were loaded in the standing angle of 100deg and the maximum load (N) and the shift (mm) were monitored. The mean maximum peak power and the shift were 1266.0 +/- 146.9 N and 13.7 +/- 2.5 mm for group 1, and 1164.7 +/- 228.2 N and 1 6.8 +/- 3.3 mm for group 2, respectively. In all cases after reaching the maximum load, a tibial fracture occurred but never a CCL rupture. In groups 3 and 4, the initial fixation failure occurred in the mean values of 375.7 +/- 81.5 and 360.4 +/- 52.0 N, respectively, and with a bigger shift of 52.3 +/- 11.9 mm and 39.4 +/- 14.6 mm, respectively, compared to group 1. A critical point of failure was the anchoring in the bone. It can be concluded that the PET/PCL substitute in the ex vivo model has mechanically comparable properties with the clinically used Mersilene, and based on its proven ability to carry stem cells it could be appropriate for partially ruptured CCL protection.

English abstract

The study deals with mechanical testing of newly developed material polyethylene terephtalate coated with polycaprolactone nanofibers in combination with biodagradable Hexalon ACL/PCL screws as a new possibility of intra-articular reinforcement of partially ruptured cranial cruciate ligament. Four groups of ex vivo models of pig stifle joints were prepared and tested: a model with intact CCL (group 1), a model with partial CCL rupture (group 2), a model with CCL rupture stabilized with 7 mm Mersilene strip (group 3), and a model with CCL rupture stabilized with 5 mm PET/PCL biomaterial strip (group 4). The models were loaded in the standing angle of 100deg and the maximum load (N) and the shift (mm) were monitored. The mean maximum peak power and the shift were 1266.0 +/- 146.9 N and 13.7 +/- 2.5 mm for group 1, and 1164.7 +/- 228.2 N and 1 6.8 +/- 3.3 mm for group 2, respectively. In all cases after reaching the maximum load, a tibial fracture occurred but never a CCL rupture. In groups 3 and 4, the initial fixation failure occurred in the mean values of 375.7 +/- 81.5 and 360.4 +/- 52.0 N, respectively, and with a bigger shift of 52.3 +/- 11.9 mm and 39.4 +/- 14.6 mm, respectively, compared to group 1. A critical point of failure was the anchoring in the bone. It can be concluded that the PET/PCL substitute in the ex vivo model has mechanically comparable properties with the clinically used Mersilene, and based on its proven ability to carry stem cells it could be appropriate for partially ruptured CCL protection.

Keywords

Knee stabilization, stifle surgery, polycaprolactone nanofibre, polyester, synthetic material, biodegradable screw

RIV year

2014

Released

01.04.2014

Publisher

University of Veterinary and Pharmaceutical Sciences in Brno

Location

Brno

Pages from

56

Pages to

60

Pages count

5

URL

Full text in the Digital Library

BibTex


@article{BUT106893,
  author="Petra {Fedorová} and Robert {Srnec} and Jan {Pěnčík} and Pavel {Schmid} and Evžen {Amler} and Lucie {Urbanová} and Alois {Nečas}",
  title="Mechanical testing of newly developed biomaterial designed for intra-articular reinforcement of partially ruptured cranial cruciate ligament: ex vivo pig model",
  annote="The study deals with mechanical testing of newly developed material polyethylene terephtalate coated with polycaprolactone nanofibers in combination with biodagradable Hexalon ACL/PCL screws as a new possibility of intra-articular reinforcement of partially ruptured cranial cruciate ligament. Four groups of ex vivo models of pig stifle joints were prepared and tested: a model with intact CCL (group 1), a model with partial CCL rupture (group 2), a model with CCL rupture stabilized with 7 mm Mersilene strip (group 3), and a model with CCL rupture stabilized with 5 mm PET/PCL biomaterial strip (group 4). The models were loaded in the standing angle of 100deg and the maximum load (N) and the shift (mm) were monitored. The mean maximum peak power and the shift were 1266.0 +/- 146.9 N and 13.7 +/- 2.5 mm for group 1, and 1164.7 +/- 228.2 N and 1 6.8 +/- 3.3 mm for group 2, respectively. In all cases after reaching the maximum load, a tibial fracture occurred but never a CCL rupture. In groups 3 and 4, the initial fixation failure occurred in the mean values of 375.7 +/- 81.5 and 360.4 +/- 52.0 N, respectively, and with a bigger shift of 52.3 +/- 11.9 mm and 39.4 +/- 14.6 mm, respectively, compared to group 1. A critical point of failure was the anchoring in the bone. It can be concluded that the PET/PCL substitute in the ex vivo model has mechanically comparable properties with the clinically used Mersilene, and based on its proven ability to carry stem cells it could be appropriate for partially ruptured CCL protection.",
  address="University of Veterinary and Pharmaceutical Sciences in Brno",
  chapter="106893",
  doi="10.2754/avb201483010055",
  institution="University of Veterinary and Pharmaceutical Sciences in Brno",
  number="1",
  volume="83",
  year="2014",
  month="april",
  pages="56--60",
  publisher="University of Veterinary and Pharmaceutical Sciences in Brno",
  type="journal article in Web of Science"
}