Publication detail

Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes

VOJTOVÁ, L. JANČÁŘ, J. JUHÁSOVÁ, J. NEČAS, A. CRHA, M. PROKS, P. PLÁNKA, L.

Original Title

Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes

English Title

Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes

Type

abstract

Language

en

Original Abstract

Mini invasive method targeted replacement of tissue defects of articular cartilage and growth plate have been proposed based on our experience in the treatment of bone defects in miniature pigs using new biopolymer composites seeded with Mesenchymal Stem Cells (MSCs). To study the regeneration of articular cartilage and growth plate, scaffold with self-supporting three-dimensional structures of collagen and chitosan fibers allowing both hydrodynamic casting MSCs and chondrocytes, and good handling, was chosen. These biodegradable scaffolds with seeded cells have successfully undergone preclinical testing on rabbits and minipigs, which were implanted at the site of damage cartilage (knee articular or distal epiphysis). The scaffold initiates tissue regeneration and resorbs in the body with controlled manner.

English abstract

Mini invasive method targeted replacement of tissue defects of articular cartilage and growth plate have been proposed based on our experience in the treatment of bone defects in miniature pigs using new biopolymer composites seeded with Mesenchymal Stem Cells (MSCs). To study the regeneration of articular cartilage and growth plate, scaffold with self-supporting three-dimensional structures of collagen and chitosan fibers allowing both hydrodynamic casting MSCs and chondrocytes, and good handling, was chosen. These biodegradable scaffolds with seeded cells have successfully undergone preclinical testing on rabbits and minipigs, which were implanted at the site of damage cartilage (knee articular or distal epiphysis). The scaffold initiates tissue regeneration and resorbs in the body with controlled manner.

Keywords

collagen, scaffold, chitosan, cartilage, growth plate, regeneration

Released

01.11.2013

Publisher

TRM, Leipzig

Location

Leipzig, Germany

Pages from

192

Pages to

192

Pages count

426

BibTex


@misc{BUT104595,
  author="Lucy {Vojtová} and Josef {Jančář} and Jana {Juhásová} and Alois {Nečas} and Michal {Crha} and Pavel {Proks} and Ladislav {Plánka}",
  title="Regeneration of articular cartilage and growth plate by 3D resorbable biopolymer composites seeded with mesenchymal stem cells and chondrocytes",
  annote="Mini invasive method targeted replacement of tissue defects of articular cartilage and growth plate have been proposed based on our experience in the treatment of bone defects in miniature pigs using new biopolymer composites seeded with Mesenchymal Stem Cells (MSCs). To study the regeneration of articular cartilage and growth plate, scaffold with self-supporting three-dimensional structures of collagen and chitosan fibers allowing both hydrodynamic casting MSCs and chondrocytes, and good handling, was chosen. These biodegradable scaffolds with seeded cells have successfully undergone preclinical testing on rabbits and minipigs, which were implanted at the site of damage cartilage (knee articular or distal epiphysis). The scaffold initiates tissue regeneration and resorbs in the body with controlled manner.",
  address="TRM, Leipzig",
  chapter="104595",
  institution="TRM, Leipzig",
  number="6",
  year="2013",
  month="november",
  pages="192--192",
  publisher="TRM, Leipzig",
  type="abstract"
}