Publication detail

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

ZÍTKA, O. CERNEI, N. HEGER, Z. MATOUŠEK, M. KOPEL, P. KYNICKÝ, J. MASAŘÍK, M. KIZEK, R. ADAM, V.

Original Title

Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine

Type

journal article in Web of Science

Language

English

Original Abstract

Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers. One of them - nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as a challenge for the development of microfluidic system with isolation by modified paramagnetic microparticles. Therefore, the aim of this study was to design a low-cost, simple, and rapidmicrofluidic system based on sarcosine isolation with modified paramagnetic microparticles and subsequent analysis on the ion exchange LC.

Keywords

Ion exchange chromatography, Magnetic nanoparticles, Microfluidic separation, Prostate cancer, Surface modification

Authors

ZÍTKA, O.; CERNEI, N.; HEGER, Z.; MATOUŠEK, M.; KOPEL, P.; KYNICKÝ, J.; MASAŘÍK, M.; KIZEK, R.; ADAM, V.

RIV year

2013

Released

1. 9. 2013

ISBN

0173-0835

Periodical

Electrophoresis

Year of study

34

Number

18

State

Federal Republic of Germany

Pages from

2639

Pages to

2647

Pages count

9

BibTex

@article{BUT103908,
  author="Ondřej {Zítka} and Natalia Vladimirovna {Cernei} and Zbyněk {Heger} and Miroslav {Matoušek} and Pavel {Kopel} and Jindřich {Kynický} and Michal {Masařík} and René {Kizek} and Vojtěch {Adam}",
  title="Microfluidic chip coupled with modified paramagnetic particles for sarcosine isolation in urine",
  journal="Electrophoresis",
  year="2013",
  volume="34",
  number="18",
  pages="2639--2647",
  doi="10.1002/elps.201300114",
  issn="0173-0835"
}