Publication detail

Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

NOVÁKOVÁ, M., PROVAZNÍK, I., BARDOŇOVÁ, J.

Original Title

Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

English Title

Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart

Type

conference paper

Language

en

Original Abstract

Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in signal morphology.

English abstract

Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in signal morphology.

Keywords

sigma ligand, heart, wavelet analysis

RIV year

2001

Released

01.01.2001

Publisher

International Federation for MEdical and Biological Engineering

Location

Pula, Chorvatsko

Pages from

418

Pages to

421

Pages count

4

BibTex


@inproceedings{BUT2823,
  author="Marie {Nováková} and Ivo {Provazník} and Jana {Kolářová}",
  title="Wavelet Analysis of the Effect of Sigma Ligand Haloperidol on Isolated Rat Heart",
  annote="Sigma receptors originally discovered in central nervous system are present also in heart muscle. Our previous experiments with sigma receptor ligands in isolated rat cardiomyocytes indicated that these receptors may play a role in modulation of contractility. It has been suggested that sigma receptors might be responsible for some adverse side effects of the classical neuroleptics, antidepressants, anxiolytics and analgesics. These effects concern nervous tissue as well as some peripheral tissues. Haloperidol is a typical sigma ligand used in everyday clinical practice for treatment of psychoses or severe agitated delirium. Its side effects - cardiac arrhythmias and eventually sudden cardiac death - are well known and have been repeatedly reported. To explain possible mechanisms underlying these effects and to get more closely to clinical observations we used a model of  isolated heart. Our data were evaluated using the wavelet analysis, an efficient tool in the assessment of short-time changes in signal morphology.",
  address="International Federation for MEdical and Biological Engineering",
  booktitle="Medicon 2001, iX Mediterranean Conference on Medical and BIological Engineering and Computing",
  chapter="2823",
  institution="International Federation for MEdical and Biological Engineering",
  year="2001",
  month="january",
  pages="418",
  publisher="International Federation for MEdical and Biological Engineering",
  type="conference paper"
}