Publication detail

Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels

HEGER, R. ZINKOVSKA, N. TRUDIČOVÁ, M. KADLEC, M. PEKAŘ, M. SMILEK, J.

Original Title

Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels

Type

journal article in Web of Science

Language

English

Original Abstract

Transport properties are one of the most crucial assets of hydrogel samples, influencing their main application potential, i.e., as drug carriers. Depending on the type of drug or the application itself, it is very important to be able to control these transport properties in an appropriate manner. This study seeks to modify these properties by adding amphiphiles, specifically lecithin. Through its self-assembly, lecithin modifies the inner structure of the hydrogel, which affects its properties, especially the transport ones. In the proposed paper, these properties are studied mainly using various probes (organic dyes) to effectively simulate drugs in simple release diffusion experiments controlled by UV-Vis spectrophotometry. Scanning electron microscopy was used to help characterize the diffusion systems. The effects of lecithin and its concentrations, as well as the effects of variously charged model drugs, were discussed. Lecithin decreases the values of the diffusion coefficient independently of the dye used and the type of crosslinking. The ability to influence transport properties is better observed in xerogel samples. The results, complementing previously published conclusions, showed that lecithin can alter a hydrogel’s structure and therefore its transport properties.

Keywords

diffusion; extracellular matrix; hydrogel; lecithin; model drugs; scanning electron microscopy; transport properties

Authors

HEGER, R.; ZINKOVSKA, N.; TRUDIČOVÁ, M.; KADLEC, M.; PEKAŘ, M.; SMILEK, J.

Released

27. 4. 2023

Publisher

MDPI

Location

Basel

ISBN

2310-2861

Periodical

Gels

Year of study

9

Number

5

State

Swiss Confederation

Pages count

18

URL

https://www.mdpi.com/2310-2861/9/5/367

Full text in the Digital Library

http://hdl.handle.net/11012/213544

BibTex

@article{BUT184017,
  author="Richard {Heger} and Natalia {Zinkovska} and Monika {Trudičová} and Martin {Kadlec} and Miloslav {Pekař} and Jiří {Smilek}",
  title="Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels",
  journal="Gels",
  year="2023",
  volume="9",
  number="5",
  pages="18",
  doi="10.3390/gels9050367",
  issn="2310-2861",
  url="https://www.mdpi.com/2310-2861/9/5/367"
}