Publication detail

2D transition metal dichalcogenide nanomaterial-based miRNA biosensors

MITREVSKA, K. MILOSAVLJEVIĆ, V. GAGIĆ, M. RICHTERA, L. ADAM, V.

Original Title

2D transition metal dichalcogenide nanomaterial-based miRNA biosensors

Type

journal article in Web of Science

Language

English

Original Abstract

MicroRNAs (miRNAs) are short oligonucleotides responsible for the regulation of basic cellular mechanisms. The detection of miRNA in clinical practice involves conventional methods (northern blot, microarrays, RT-qPCR) that provide good sensitivity and specificity. However, their high cost and time-consuming nature prevent their implementation as routine analysis. Biosensors, as alternative detection platforms, can compensate for these flaws, providing good sensitivity and specificity as well as low prices per assay and fast generation of results; therefore, biosensors may ultimately replace conventional methods. The fast progress in nanotechnology has created new prospects in biosensor fabrication, presenting a selection of nanomaterials compatible for the detection of various biomolecules. Two-dimensional transition metal dichalcogenides (2D TMDCs) demonstrate promising qualities, such as biocompatibility, a large surface area for detection and diverse possibilities for altering electrochemical and optical properties; hence, an improved detection performance can be achieved. In this review, the recent progress in biosensor fabrication for detecting miRNAs based on 2D TMDCs is summarized and supported by the basic understanding of miRNA biosynthetic pathways and detection methods. Additionally, insight into the structure and properties of TMDCs will be disclosed as well as suitable methods for their synthesis and the mechanisms for tuning their properties.

Keywords

Transition metals; Dichalcogenides; Nanomaterials; miRNA; Biosensors

Authors

MITREVSKA, K.; MILOSAVLJEVIĆ, V.; GAGIĆ, M.; RICHTERA, L.; ADAM, V.

Released

30. 6. 2021

ISBN

2352-9407

Periodical

Applied Materials Today

Year of study

23

Number

101043

State

Kingdom of the Netherlands

Pages from

1

Pages to

23

Pages count

23

URL

https://doi.org/10.1016/j.apmt.2021.101043

BibTex

@article{BUT172057,
  author="MITREVSKA, K. and MILOSAVLJEVIĆ, V. and GAGIĆ, M. and RICHTERA, L. and ADAM, V.",
  title="2D transition metal dichalcogenide nanomaterial-based miRNA biosensors",
  journal="Applied Materials Today",
  year="2021",
  volume="23",
  number="101043",
  pages="1--23",
  doi="10.1016/j.apmt.2021.101043",
  issn="2352-9407",
  url="https://doi.org/10.1016/j.apmt.2021.101043"
}