Publication detail

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

BEZROUK, A. HOSSZÚ, T. HROMÁDKO, L. KOPEČEK, M. OLMROVÁ ZMRHALOVÁ, Z. SMUTNÝ, M. KRULICHOVÁ, I. MACÁK, J. KREMLÁČEK, J.

Original Title

Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance

Type

journal article in Web of Science

Language

English

Original Abstract

Biodegradable stents are promising treatments for many diseases, e.g., coronary artery disease, urethral diseases, tracheal diseases, and esophageal strictures. The mechanical properties of biodegradable stent materials play a key role in the safety and efficacy of treatment. In particular, insufficient creep resistance of the stent material could result in premature stent collapse or narrowing. Commercially available biodegradable self-expandable SX-ELLA stents made of polydioxanone monofilament were tested. A new, simple, and affordable method to measure the shear modulus of tiny viscoelastic wires is presented. The important mechanical parameters of the polydioxanone filament were obtained: the median Young's modulus was (E) over tilde = 958 (922, 974) MPa and the shear modulus was (G) over tilde= 357 (185, 387) MPa, resulting in a Poisson's ratio of nu = 0.34. The SX-ELLA stents exhibited significant force relaxation due to the stress relaxation of the polydioxanone monofilament, approximately 19% and 36% 10 min and 48 h after stent application, respectively. However, these results were expected, and the manufacturer and implanting clinician should be aware of the known behavior of these biodegradable materials. If possible, a biodegradable stent should be designed considering therapeutic force rather than initial force. Additionally, new and more advanced biodegradable shape-memory polymers should be considered for future study and use.

Keywords

BENIGN ESOPHAGEAL STRICTURES; SUTURE MATERIALS; MEMORY; DEGRADATION; COMPOSITES; STRENGTH; BEHAVIOR; FIBERS; MODELS; CREEP

Authors

BEZROUK, A.; HOSSZÚ, T.; HROMÁDKO, L.; KOPEČEK, M.; OLMROVÁ ZMRHALOVÁ, Z.; SMUTNÝ, M.; KRULICHOVÁ, I.; MACÁK, J.; KREMLÁČEK, J.

Released

8. 7. 2020

Publisher

PLOS

Location

SAN FRANCISCO

ISBN

1932-6203

Periodical

PLOS ONE

Year of study

15

Number

7

State

United States of America

Pages from

1

Pages to

16

Pages count

16

URL

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235842

Full text in the Digital Library

http://hdl.handle.net/11012/196572

BibTex

@article{BUT170376,
  author="Aleš {Bezrouk} and Tomáš {Hosszú} and Luděk {Hromádko} and Zuzana {Olmrová Zmrhalová} and Martin {Kopeček} and Martin {Smutný} and Iva Selke {Krulichová} and Jan {Macák} and Jan {Kremláček}",
  title="Mechanical properties of a biodegradable self-expandable polydioxanone monofilament stent: In vitro force relaxation and its clinical relevance",
  journal="PLOS ONE",
  year="2020",
  volume="15",
  number="7",
  pages="1--16",
  doi="10.1371/journal.pone.0235842",
  issn="1932-6203",
  url="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235842"
}