Publication detail

Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

ŠŤASTNÁ, E. ČÁSTKOVÁ, K. RÁHEĽ, J.

Original Title

Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

Type

journal article in Web of Science

Language

English

Original Abstract

Nanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.

Keywords

electrospinning; nanofibers; polycaprolactone; hydroxyapatite; tissue engineering; atmospheric pressure argon plasma

Authors

ŠŤASTNÁ, E.; ČÁSTKOVÁ, K.; RÁHEĽ, J.

Released

20. 8. 2020

Publisher

MDPI

Location

Basel, Švýcarská konfederace

ISBN

2073-4360

Periodical

Polymers

Year of study

12

Number

9

State

Swiss Confederation

Pages from

1

Pages to

16

Pages count

16

URL

https://www.mdpi.com/2073-4360/12/9/1877

Full text in the Digital Library

http://hdl.handle.net/11012/194808

BibTex

@article{BUT164786,
  author="Eva {Šťastná} and Klára {Částková} and Jozef {Ráheĺ}",
  title="Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers",
  journal="Polymers",
  year="2020",
  volume="12",
  number="9",
  pages="1--16",
  doi="10.3390/polym12091877",
  issn="2073-4360",
  url="https://www.mdpi.com/2073-4360/12/9/1877"
}