Publication detail

An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

ASHRAFI, A.. KOPEL, P. RICHTERA, L.

Original Title

An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes

Type

journal article in Web of Science

Language

English

Original Abstract

The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni3(abb)3(H2O)3(µ-ttc)](ClO4)3 (1), [Ni3(tebb)3(H2O)3(µ-ttc)](ClO4)3·H2O (2), and [Ni3(pmdien)3(µ-ttc)](ClO4)3 (3), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH3 = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex 3 was investigated. All the complexes show antibacterial activity against Staphylococcus aureus and Escherichia coli to different extents. The cytotoxic activity of complex 3 and ttcNa3 were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex 3 possesses the cytotoxic activity against the tested cell lines, whereas ttcNa3 did not show any cytotoxic activity.

Keywords

nickel complexes; trithiocyanuric acid; trimercaptotriazine; cyclic voltammetry

Authors

ASHRAFI, A..; KOPEL, P.; RICHTERA, L.

Released

10. 4. 2020

Publisher

MDPI

ISBN

1996-1944

Periodical

Materials

Year of study

13

Number

7

State

Swiss Confederation

Pages from

1

Pages to

8

Pages count

8

URL

https://www.mdpi.com/1996-1944/13/7/1782/htm

Full text in the Digital Library

http://hdl.handle.net/11012/186820

BibTex

@article{BUT163533,
  author="Amirmansoor {Ashrafi} and Pavel {Kopel} and Lukáš {Richtera}",
  title="An Investigation on the Electrochemical Behavior and Antibacterial and Cytotoxic Activity of Nickel Trithiocyanurate Complexes",
  journal="Materials",
  year="2020",
  volume="13",
  number="7",
  pages="1--8",
  doi="10.3390/ma13071782",
  issn="1996-1944",
  url="https://www.mdpi.com/1996-1944/13/7/1782/htm"
}