Publication detail

Bisphosphonates-much more than only drugs for bone diseases

KUŹNIK, A. PAŹDZIERNIOK-HOLEWA, A. JEWULA, P. KUŹNIK, N.

Original Title

Bisphosphonates-much more than only drugs for bone diseases

Type

journal article in Web of Science

Language

English

Original Abstract

alpha,alpha-Bisphosphonates (BPs) are well established in the treatment of bone diseases such as osteoporosis and Paget's disease. Their successful application originates from their high affinity to hydroxyapatite. While the initially appreciated features of BPs are already beneficial to many patients, recent developments have further expanded their pleiotropic applications. This review describes the background of the interactions of BPs with bone cells that form the basis of the classical treatment. A better understanding of the mechanism behind their interactions allows for the parallel application of BPs against bone cancer and metastases followed by palliative pain relief. Targeted therapy with bone-seeking BPs coupled with a diagnostic agent in one particle resulted in theranostics which is also described here. For example, in such a system, BP moieties are bound to contrast agents used in magnetic resonance imaging or radionuclides used in positron emission tomography. In addition, another example of the pleiotropic function of BPs which involves targeting the imaging agents to bone tissues accompanied by pain reduction is presented in this work.

Keywords

Bisphosphonate; Bone disease; Osteoporosis; Paget's disease; Bone imaging; Bone metastasis

Authors

KUŹNIK, A.; PAŹDZIERNIOK-HOLEWA, A.; JEWULA, P.; KUŹNIK, N.

Released

5. 1. 2020

Publisher

ELSEVIER

Location

AMSTERDAM

ISBN

0014-2999

Periodical

European Journal of Pharmacology

Year of study

866

Number

1

State

Kingdom of the Netherlands

Pages from

1

Pages to

16

Pages count

16

URL

https://www.sciencedirect.com/science/article/pii/S0014299919307253?via%3Dihub

BibTex

@article{BUT161177,
  author="Anna {Kuźnik} and Agnieszka {Październiok-Holewa} and Pawel {Jewula} and Nikodem {Kuźnik}",
  title="Bisphosphonates-much more than only drugs for bone diseases",
  journal="European Journal of Pharmacology",
  year="2020",
  volume="866",
  number="1",
  pages="1--16",
  doi="10.1016/j.ejphar.2019.172773",
  issn="0014-2999",
  url="https://www.sciencedirect.com/science/article/pii/S0014299919307253?via%3Dihub"
}