Publication detail

Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering

MANAKHOV, A. PERMYAKOVA, E. ERSHOV, S. SHEVEYKO, A. KOVALSKII, A. POLČÁK, J. ZHITNYAK, I. GLOUSHANKOVA, N. ZAJÍČKOVÁ, L. SHTANSKY, D.

Original Title

Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering

Type

journal article in Web of Science

Language

English

Original Abstract

This work deals with the deposition of bioactive TiCaPCON films onto biodegradable polycaprolactone (PCL) nanofibers using magnetron sputtering for bone tissue engineering. Low melting point of PCL nanofibers requires a careful tuning of processing parameters in order to achieve high film quality and avoid substrate degradation. SEM and XPS analyses showed that, with the magnetron current of 2 A, the TiCaPCON films deposited onto PCL nanofibers and Si wafers exhibit similar chemical states hereby indicating that the nanofiber structure is not affected by the deposition process. In vitro biological tests indicated that the osteoblasts adhesion and proliferation as well the ALP activity can be significantly improved by depositing the TiCaPCON film onto PCL. The reported findings suggest a new strategy for the preparation of biodegradable polymer-based biomaterials for bone tissue engineering.

Keywords

PCL; TiCaPCON; Nanofibers; Magnetron sputtering; XPS; Osteoblast

Authors

MANAKHOV, A.; PERMYAKOVA, E.; ERSHOV, S.; SHEVEYKO, A.; KOVALSKII, A.; POLČÁK, J.; ZHITNYAK, I.; GLOUSHANKOVA, N.; ZAJÍČKOVÁ, L.; SHTANSKY, D.

Released

15. 6. 2019

Publisher

ELSEVIER SCIENCE BV

Location

AMSTERDAM

ISBN

0169-4332

Periodical

Applied Surface Science

Year of study

479

Number

1

State

Kingdom of the Netherlands

Pages from

796

Pages to

802

Pages count

7

URL

https://www.sciencedirect.com/science/article/pii/S0169433219305057?via%3Dihub

BibTex

@article{BUT161050,
  author="Anton {Manakhov} and Elizaveta {Permyakova} and Sergey {Ershov} and A.N. {Sheveyko} and Andrey {Kovalskii} and Josef {Polčák} and I.Y. {Zhitnyak} and Natalia A. {Gloushankova} and Lenka {Zajíčková} and Dmitry V. {Shtansky}",
  title="Bioactive TiCaPCON-coated PCL nanofibers as a promising material for bone tissue engineering",
  journal="Applied Surface Science",
  year="2019",
  volume="479",
  number="1",
  pages="796--802",
  doi="10.1016/j.apsusc.2019.02.163",
  issn="0169-4332",
  url="https://www.sciencedirect.com/science/article/pii/S0169433219305057?via%3Dihub"
}